Ahluwalia B, Jackson M A, Jones G W, Williams A O, Rao M S, Rajguru S
Cancer. 1981 Nov 15;48(10):2267-73. doi: 10.1002/1097-0142(19811115)48:10<2267::aid-cncr2820481023>3.0.co;2-r.
Epidemiologic data reveal that the incidence rate of prostate gland carcinoma among the black population in the United States (US) is several times higher than among Nigerians. A collaborative study between the two countries was undertaken, and blood hormone (testosterone [T], dihydrotestosterone [DHT], estrone [E1], estradiol [E2], and prolactin [P1]), total acid phosphatase (TP), and prostatic acid phosphatase (PAP) profiles in the two population groups were compared. In the US groups (patients and controls) there were significantly higher levels of T (P less than 0.01) and E1 (P less than 0.05) compared with the Nigerians. Also, the US patients had significantly higher levels of T (P less than 0.05) and E1 (P less than 0.01) compared with their matched controls. In the Nigerians T but not E1 levels were significantly lower (P less than 0.05) in patients compared with controls. DHT, E2, and P1 were not significantly different in patients and controls between and within the populations. Nigerian patients had higher levels (P less than 0.001) of TP and PAP compared with US patients. It is concluded that differences in blood hormone profiles in the two population groups are based on factors other than the genetic makeup of the populations.
流行病学数据显示，美国黑人人群中前列腺癌的发病率比尼日利亚人高出数倍。两国开展了一项合作研究，比较了这两个人群组的血液激素（睾酮 [T]、双氢睾酮 [DHT]、雌酮 [E1]、雌二醇 [E2] 和催乳素 [P1]）、总酸性磷酸酶（TP）和前列腺酸性磷酸酶（PAP）水平。与尼日利亚人相比，美国组（患者和对照组）的T（P<0.01）和E1（P<0.05）水平显著更高。此外，与匹配的对照组相比，美国患者的T（P<0.05）和E1（P<0.01）水平显著更高。在尼日利亚人中，与对照组相比，患者的T水平显著较低（P<0.05），但E1水平无显著差异。人群之间和人群内部的患者与对照组中，DHT、E2和P1无显著差异。与美国患者相比，尼日利亚患者的TP和PAP水平更高（P<0.001）。得出的结论是，两个人群组血液激素水平的差异是基于人群基因组成以外的因素。
