Lees R E, Steele R, Wardle D
J Epidemiol Community Health. 1985 Sep;39(3):227-30. doi: 10.1136/jech.39.3.227.
A study was conducted to investigate the association of cancer of the prostate with historical records of previous venereal disease and treatment with arsenical drugs. Eighty-three cancer cases were each age matched with two male controls--one with benign prostatic hypertrophy and one other non-cancer patient. Analysis from pooled data showed a statistically significant difference for syphilis infection between cases and controls at p less than 0.05; odds ratio 2.9. Matched pair analysis maintained p less than 0.05 significance for the first control group but odds ratios were 5.5 and 2.75 in respect of control groups 1 and 2. The mean age at which venereal infection was acquired was higher for syphilis than for gonorrhoea, but the mean age at diagnosis of cancer was younger for the syphilis group; there was a statistically significant difference between the mean at cancer diagnosis of those who had syphilis and those who had no record of previous venereal infection (t = 2.18, df 70, p less than 0.05). No association was demonstrated for history of treatment with arsenical drugs.
开展了一项研究，以调查前列腺癌与既往性病历史记录以及砷剂治疗之间的关联。83例癌症病例均与两名男性对照进行年龄匹配——一名患有良性前列腺增生，另一名为非癌症患者。汇总数据分析显示，病例组和对照组在梅毒感染方面存在统计学显著差异，p值小于0.05；比值比为2.9。配对分析显示，第一对照组的p值保持小于0.05的显著性，但对照组1和对照组2的比值比分别为5.5和2.75。梅毒感染的平均年龄高于淋病，但梅毒组癌症诊断的平均年龄更年轻；有梅毒史者与无既往性病感染记录者在癌症诊断时的平均年龄存在统计学显著差异（t = 2.18，自由度70，p值小于0.05）。未发现砷剂治疗史与前列腺癌之间存在关联。
