Schwebke J R, Lawing L F
Department of Medicine, University of Alabama at Birmingham, USA.
Sex Transm Dis. 2001 Apr;28(4):195-9. doi: 10.1097/00007435-200104000-00002.
Mobiluncus spp are highly associated with bacterial vaginosis, but their role in its pathogenesis is unknown. The authors used polymerase chain reaction (PCR) to compare the prevalence of Mobiluncus in women with and without bacterial vaginosis.
To compare the prevalence of Mobiluncus spp among women with and without bacterial vaginosis and to compare the sensitivities of PCR and Gram stain for detection.
Vaginal specimens from 74 women were analyzed by PCR and Gram stain for the presence of Mobiluncus spp. Comparisons were made between the prevalence of this organism between the two cohorts and between the Gram stain and PCR detection methods.
Mobiluncus was detected by PCR in 84.5% of women with bacterial vaginosis and in 38% of women without infection. M curtisii was rarely detected in the latter group, though it was found in 65.3% of women with bacterial vaginosis. The sensitivity and specificity of Gram stain compared with PCR were 46.9% and 100%, respectively.
Mobiluncus is more common in healthy women than previously suspected, with M mulieris as the predominant species. The significant difference in the prevalence of M curtisii between women with bacterial vaginosis and uninfected women suggests that this species could be involved in the pathogenesis of bacterial vaginosis.
动弯杆菌属与细菌性阴道病高度相关，但其在发病机制中的作用尚不清楚。作者使用聚合酶链反应（PCR）比较患有和未患有细菌性阴道病的女性中动弯杆菌的患病率。
比较患有和未患有细菌性阴道病的女性中动弯杆菌属的患病率，并比较PCR和革兰氏染色检测的敏感性。
对74名女性的阴道标本进行PCR和革兰氏染色分析，以检测动弯杆菌属的存在。比较了两个队列中该微生物的患病率以及革兰氏染色和PCR检测方法之间的差异。
PCR检测发现，84.5%的细菌性阴道病女性中存在动弯杆菌，未感染的女性中这一比例为38%。在后一组中很少检测到柯氏动弯杆菌，而在65.3%的细菌性阴道病女性中发现了该菌。与PCR相比，革兰氏染色的敏感性和特异性分别为46.9%和100%。
动弯杆菌在健康女性中比以前怀疑的更为常见，其中多形动弯杆菌是主要菌种。患有细菌性阴道病的女性与未感染女性之间柯氏动弯杆菌患病率的显著差异表明，该菌种可能参与了细菌性阴道病的发病机制。
