Kongara K, Varilek G, Soffer E E
Cleveland Clinic Foundation, Ohio 44195, USA.
Dig Dis Sci. 2001 Mar;46(3):606-9. doi: 10.1023/a:1005615703009.
Growth factors, such as epidermal growth factor (EGF), are known to protect upper gut mucosa against irritants and to enhance healing of ulcerative lesions in animal models. A number of salivary growth factors are found in human saliva. The aim of this study was to determine if salivary growth factors and cytokines are deficient in patients with esophagitis or with Barrett's metaplasia. Fifteen healthy subjects, eight patients with esophagitis, and 13 patients with Barrett's metaplasia were included. Salivary concentration of EGF, FGF, IL-1, and IL-6 were measured during esophageal saline and hydrochloric acid perfusion and in the postprandial state. There was no statistically significant difference in the concentration of EGF or cytokines among the three study groups in each experimental condition or among the three experimental conditions in each group. FGF basic could not be detected in saliva. In conclusion, these findings do not support the hypothesis that a deficiency in salivary growth factors or cytokines plays a significant role in the development of mild to moderate reflux esophagitis or Barrett's metaplasia.
生长因子，如表皮生长因子（EGF），已知可保护上消化道黏膜免受刺激物侵害，并在动物模型中促进溃疡性病变的愈合。在人类唾液中发现了多种唾液生长因子。本研究的目的是确定食管炎或巴雷特化生患者的唾液生长因子和细胞因子是否缺乏。纳入了15名健康受试者、8名食管炎患者和13名巴雷特化生患者。在食管灌注生理盐水和盐酸期间以及餐后状态下测量了唾液中EGF、FGF、IL-1和IL-6的浓度。在每种实验条件下，三个研究组之间或每组的三种实验条件之间，EGF或细胞因子的浓度均无统计学显著差异。在唾液中未检测到碱性成纤维细胞生长因子（FGF basic）。总之，这些发现不支持唾液生长因子或细胞因子缺乏在轻度至中度反流性食管炎或巴雷特化生的发生中起重要作用这一假设。
