Yang Xiao-Jun, Jiang Hong-Mei, Hou Xiao-Hua, Song Jun
Xiao-Jun Yang, Hong-Mei Jiang, Xiao-Hua Hou, Jun Song, Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China.
World J Gastroenterol. 2015 Apr 14;21(14):4302-9. doi: 10.3748/wjg.v21.i14.4302.
To explore the role of psychological factors in gastroesophageal reflux disease (GERD) and their effect on quality of life (QoL) of GERD patients.
A total of 279 consecutive patients with typical symptoms and 100 healthy controls were enrolled in the study. All of the participants were evaluated with the Zung Self-Rating Anxiety Scale (ZSAS), the Zung Self-Rating Depression Scale (ZSDS) and the SF-36 questionnaire. The scores for anxiety, depression and QoL of the two groups were analyzed. The correlation between psychological factors and QoL was also analyzed.
Compared with healthy controls (34.70 ± 8.00), the scores of ZSAS in the non-erosive reflux disease (NERD) group (48.27 ± 10.34) and the reflux esophagitis (RE) group (45.38 ± 10.27) were significantly higher (P < 0.001). The mean ZSAS score of the NERD group was significantly higher than that of the RE group (P = 0.01). Compared with healthy controls (37.61 ± 8.44), the mean ZSDS scores were significantly higher in the NERD group (49.65 ± 11.09, P < 0.001) and the RE group (46.76 ± 11.83, P < 0.001). All dimensions of the SF-36 form were negatively correlated with the SAS and SDS scores in patients with NERD and RE (P < 0.05). According to the SF-36 form, vitality, mental health and social functioning were significantly correlated with symptoms of depression in patients with NERD and RE. General health was obviously affected by symptoms of depression in patients with NERD (P < 0.05).
Anxiety and depression may play an important role in the occurrence of GERD and especially that of NERD. The QoL of patients with GERD is reduced by anxiety and depression.
探讨心理因素在胃食管反流病（GERD）中的作用及其对GERD患者生活质量（QoL）的影响。
本研究共纳入279例有典型症状的连续患者和100例健康对照者。所有参与者均采用zung自评焦虑量表（ZSAS）、zung自评抑郁量表（ZSDS）和SF-36问卷进行评估。分析两组的焦虑、抑郁和生活质量得分。还分析了心理因素与生活质量之间的相关性。
与健康对照组（34.70±8.00）相比，非糜烂性反流病（NERD）组（48.27±10.34）和反流性食管炎（RE）组（45.38±10.27）的ZSAS得分显著更高（P<0.001）。NERD组的平均ZSAS得分显著高于RE组（P = 0.01）。与健康对照组（37.61±8.44）相比，NERD组（49.65±11.09，P<0.001）和RE组（46.76±11.83，P<0.001）的平均ZSDS得分显著更高。SF-36量表的所有维度与NERD和RE患者的SAS和SDS得分均呈负相关（P<0.05）。根据SF-36量表，活力、心理健康和社会功能与NERD和RE患者的抑郁症状显著相关。NERD患者的总体健康明显受到抑郁症状的影响（P<0.05）。
焦虑和抑郁可能在GERD尤其是NERD的发生中起重要作用。焦虑和抑郁会降低GERD患者的生活质量。
