Fenrich F R, Beaulieu C, Allen P S
Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada.
NMR Biomed. 2001 Apr;14(2):133-9. doi: 10.1002/nbm.685.
A discussion is presented of the evaluation of multiple relaxation components from water protons in biological tissue. The principal focus is to draw attention to the way in which limitations in the raw NMR data, such as signal-to-noise ratio, data sampling density and acquisition window width, affect the precision and resolution in the processed multiple component solution of the return to thermal equilibrium. The second issue discussed is the interpretation of these multiple components in terms of microstructural compartments of the biological sample and, thirdly, we outline some of the successes in determining regional and pathological variations in microstructure in the human body in-vivo, using the technique of multiple relaxation components.
本文讨论了对生物组织中水质子的多个弛豫成分的评估。主要关注点是提请注意原始核磁共振（NMR）数据中的局限性，如信噪比、数据采样密度和采集窗口宽度，如何影响处理后的热平衡恢复多组分解决方案中的精度和分辨率。讨论的第二个问题是根据生物样品的微观结构隔室对这些多组分进行解释，第三，我们概述了使用多弛豫成分技术在人体体内确定微观结构的区域和病理变化方面取得的一些成功。
