Le Bihan D
Département de Recherche Médicale, Commissariat à l'Energie Atomique, Orsay, France.
NMR Biomed. 1995 Nov-Dec;8(7-8):375-86. doi: 10.1002/nbm.1940080711.
Diffusion NMR is the only method available today that noninvasively provides information on molecular displacements over distances comparable to cell dimensions. This information can be used to infer tissue microstructure and microdynamics. However, data may be fairly difficult to interpret in biological tissues which differ markedly from the theoretical "infinite isotrope medium", as many factors may affect the NMR signal. The object of this paper is to analyze the expected effects of temperature, restriction, hindrance, membrane permeability, anisotropy and tissue inhomogeneity on the diffusion measurements. Powerful methods, such as q-space imaging, diffusion tensor imaging and diffusion spectroscopy of metabolites further enhance the specificity of the information obtained from diffusion NMR experiments.
扩散核磁共振是目前唯一可用的方法，它能以非侵入性方式提供与细胞尺寸相当距离上分子位移的信息。该信息可用于推断组织微观结构和微观动力学。然而，在与理论上的“无限各向同性介质”显著不同的生物组织中，数据可能相当难以解释，因为许多因素可能影响核磁共振信号。本文的目的是分析温度、限制、阻碍、膜通透性、各向异性和组织不均匀性对扩散测量的预期影响。强大的方法，如q空间成像、扩散张量成像和代谢物扩散光谱，进一步提高了从扩散核磁共振实验获得信息的特异性。
