Imamura H, Miyamoto N, Uchida K, Teshima K, Masuda Y, Kobata D
Laboratory of Nutrition and Exercise Physiology, Department of Food and Nutrition, Nakamura Gakuen University.
J Physiol Anthropol Appl Human Sci. 2001 Jan;20(1):1-6. doi: 10.2114/jpa.20.1.
The relationship of cigarette smoking with blood pressure and serum lipids and lipoproteins was studied in the 3934 middle-aged women aged 40 to 59 years. After adjusting age, body mass index (BMI), alcohol intake and physical activity scores, the mean systolic and diastolic blood pressures (SBP and DEP, respectively) did not indicate dose-dependent relationships. The largest significant mean differences in SBP (4.6 mmHg), DBP (3.9 mmHg), high density lipoprotein cholesterol (HDL-C) (9.6 mg/dL), ratio of total cholesterol to HDL-C (TC/HDL-C) (0.8), triglycerides (TG) (22.9 mg/dL) and the logarithmic transformation of TG (Log TG) (0.26) were found between the non-smokers and smokers. When age, BMI, alcohol intake and physical activity scores were included in the forward stepwise multiple regression analyses, there were negative relationships found for cigarette smoking and SBP, DBP and HDL-C and positive relationships for cigarette smoking and TC/HDL-C, TG, Log TG and low density lipoprotein cholesterol. Although the results are somewhat variable, the present study shows cigarette smoking is negatively associated with SBP and DBP and unfavorably associated with serum lipids and lipoproteins in middle-aged women.
对3934名年龄在40至59岁之间的中年女性，研究了吸烟与血压、血清脂质及脂蛋白之间的关系。在调整年龄、体重指数（BMI）、酒精摄入量及身体活动得分后，平均收缩压和舒张压（分别为SBP和DBP）未显示出剂量依赖关系。在不吸烟者与吸烟者之间，发现SBP（4.6 mmHg）、DBP（3.9 mmHg）、高密度脂蛋白胆固醇（HDL-C）（9.6 mg/dL）、总胆固醇与HDL-C的比值（TC/HDL-C）（0.8）、甘油三酯（TG）（22.9 mg/dL）以及TG的对数转换值（Log TG）（0.26）存在最大显著平均差异。当将年龄、BMI、酒精摄入量及身体活动得分纳入向前逐步多元回归分析时，发现吸烟与SBP、DBP及HDL-C呈负相关，与TC/HDL-C、TG、Log TG及低密度脂蛋白胆固醇呈正相关。尽管结果存在一定差异，但本研究表明，吸烟与中年女性的SBP和DBP呈负相关，与血清脂质及脂蛋白呈不利相关。
