Rigo P, Murray M, Taylor D R, Weisfeldt M L, Strauss H W, Pitt B
Circulation. 1975 Jun;51(6):1064-70. doi: 10.1161/01.cir.51.6.1064.
One hundred and eleven patients with transmural (TMI) and 49 with nontransmural myocardial infarction (NTMI) underwent hemodynamic investigation within 24 hours of onset of symptoms. Patients with NTMI were subdivided into those with ST-segment or T-wave changes alone with a normal QRS complex (NTMI-A) and a group with QRS abnormalities that did not satisfy the criteria for TMI (NTMI-B). Those with TMI had a significantly higher peak creatine phosphokinase (CPK) than those with NTMI: 840 plus or minus 99 and 336 plus or minus 69, respectively, P smaller than 0.05. There was not difference in peak CPK between those with NTMI-A and B. The incidence of arrhythmias and cardiac failure, and routine hemodynamic findings except for left ventricular filling pressure were similar in those with TMI and NTMI. There was not significant difference in in-hospital mortality between those with TMI (22%) and NTMI (33%). There was however a significant difference in in-hospital mortality between those with NTMI-A (0%) and NTMI-B (27%, P smaller than 0.05). The late mortality in those surviving their initial hospitalization was also not different between those with TMI (18%) and NTMI (19%) during a mean follow-up period of 20.2 months. In contrast to the in-hospital mortality those with NTMI-A had a late mortality similar to those with NTMI-B and those with TMI.
111例透壁性心肌梗死（TMI）患者和49例非透壁性心肌梗死（NTMI）患者在症状发作后24小时内接受了血流动力学检查。NTMI患者被细分为单纯ST段或T波改变且QRS波群正常的患者（NTMI-A）和QRS异常但不符合TMI标准的患者（NTMI-B）。TMI患者的肌酸磷酸激酶（CPK）峰值显著高于NTMI患者：分别为840±99和336±69，P<0.05。NTMI-A和NTMI-B患者的CPK峰值无差异。TMI和NTMI患者的心律失常和心力衰竭发生率以及除左心室充盈压外的常规血流动力学结果相似。TMI患者（22%）和NTMI患者（33%）的院内死亡率无显著差异。然而，NTMI-A患者（0%）和NTMI-B患者（27%，P<0.05）的院内死亡率存在显著差异。在平均20.2个月的随访期内，初次住院存活患者的晚期死亡率在TMI患者（18%）和NTMI患者（19%）之间也无差异。与院内死亡率相反，NTMI-A患者的晚期死亡率与NTMI-B患者和TMI患者相似。
