Thanavaro S, Krone R J, Kleiger R E, Province M A, Miller J P, deMello V R, Oliver G C
Circulation. 1980 Jan;61(1):29-33. doi: 10.1161/01.cir.61.1.29.
We studied the in-hospital mortality and morbidity of 745 patients who had suffered a first myocardial infarction. One hundred twenty-four patients (16.6%) had nontransmural infarction and 621 (83.4%) had transmural infarction. Both groups of patients were similar in the distribution of age, sex, and coronary risk factors. Patients with nontransmural infarction had a significantly lower mortality (3% vs 11%, p less than 0.01) and a lower prevalence of premature ventricular complexes (81% vs 88%, p less than 0.05). The patients with transmural infarction were distributed evenly among the three subgroups with peak SGOT levels less than 120 units, 120-240 units and more than 240 units (31%, 34% and 35%, respectively), while most patients with nontransmural infarction (60%) had peak SGOT levels less than 120 units (p less than 0.0001). When the in-hospital mortality and morbidity were compared between the parallel subgroups, the prognosis of patients with the two types of infarctions was similar. This study shows that the peak SGOT level is more important than the type of infarction in determining the acute mortality and morbidity of first myocardial infarction.
我们研究了745例首次发生心肌梗死患者的院内死亡率和发病率。124例患者（16.6%）发生非透壁性梗死，621例患者（83.4%）发生透壁性梗死。两组患者在年龄、性别和冠状动脉危险因素分布方面相似。非透壁性梗死患者的死亡率显著较低（3%对11%，p<0.01），室性早搏的发生率也较低（81%对88%，p<0.05）。透壁性梗死患者在血清谷草转氨酶（SGOT）峰值水平低于120单位、120 - 240单位和高于240单位的三个亚组中分布均匀（分别为31%、34%和35%），而大多数非透壁性梗死患者（60%）的SGOT峰值水平低于120单位（p<0.0001）。当对平行亚组的院内死亡率和发病率进行比较时，两种梗死类型患者的预后相似。本研究表明，在确定首次心肌梗死的急性死亡率和发病率方面，SGOT峰值水平比梗死类型更重要。
