慢性肾功能衰竭患者的血浆氨基酸和蛋白质水平以及口服必需氨基酸补充剂所引起的变化。

Plasma amino acids and protein levels in chronic renal failure and changes caused by oral supplements of essential amino acids.

Young G A, Keogh J B, Parsons F M

Clin Chim Acta. 1975 Jun 2;61(2):205-13. doi: 10.1016/0009-8981(75)90316-2.

Abstract

Plasma amino acids and six proteins have been measured in patients with chronic renal failure receiving low protein diets before and after oral supplementation with essential amino acids. 2. All the patients on low protein diets had a lower percentage of essential amino acids in their plasma than normal subjects but after supplementation, plasma levels increased significantly with minimal increase in non-essential amino acids or urea nitrogen. 3. Mean levels of plasma transferrin, complement C3 and globulin Gc were lower and plasma prealbumin higher in patients than in normal subjects. Plasma complement C4 and albumin were not different from normal. 4. Seven out of nine patients who tolerated the supplementation showed a significant increase in plasma transferrin, prealbumin and complement C3 but not in complement C4, globulin Gc or albumin. 5. Correlations between the percentage of essential amino acids and each of plasma transferrin, prealbumin and complement C3 and also between several of the plasma proteins further substantiate their value in the assessment of dietary intake in chronic renal failure. 6. The value of amino acid supplementation on low protein diets in chronic renal failure is discussed in relation to these observations.

摘要

对接受低蛋白饮食的慢性肾衰竭患者在口服补充必需氨基酸前后的血浆氨基酸和六种蛋白质进行了测定。2. 所有接受低蛋白饮食的患者血浆中必需氨基酸的百分比均低于正常受试者，但补充后，血浆水平显著升高，而非必需氨基酸或尿素氮的增加 minimal。3. 患者血浆转铁蛋白、补体C3和球蛋白Gc的平均水平低于正常受试者，而血浆前白蛋白高于正常受试者。血浆补体C4和白蛋白与正常无差异。4. 九名耐受补充的患者中有七名血浆转铁蛋白、前白蛋白和补体C3显著增加，但补体C4、球蛋白Gc或白蛋白未增加。5. 必需氨基酸百分比与血浆转铁蛋白、前白蛋白和补体C3中的每一种之间以及几种血浆蛋白之间的相关性进一步证实了它们在评估慢性肾衰竭饮食摄入量中的价值。6. 结合这些观察结果讨论了慢性肾衰竭患者在低蛋白饮食中补充氨基酸的价值。