Axford J
Academic Unit for Musculoskeletal Disease, St George's Hospital Medical School, Cranmer Terrace, London, UK SW17 0RE.
Trends Immunol. 2001 May;22(5):237-9. doi: 10.1016/s1471-4906(01)01890-7.
Proteins essential to normal cell physiology are usually glycosylated and variation in their glycosylation patterns often leads to changes in their function. Changes in glycosylation pattern can also be associated with disease. It is now becoming increasingly clear how important it is to understand these changes, to gain insight into their involvement in disease mechanisms and the potential for novel therapeutic interventions.
对正常细胞生理至关重要的蛋白质通常会被糖基化，其糖基化模式的变化往往会导致其功能改变。糖基化模式的变化也可能与疾病相关。现在越来越清楚的是，了解这些变化、深入了解它们在疾病机制中的作用以及新型治疗干预的潜力是多么重要。
