Groenink M, de Roos A, Mulder B J, Verbeeten B, Timmermans J, Zwinderman A H, Spaan J A, van der Wall E E
Department of Cardiology, Academic Medical Center, Amsterdam, the Netherlands.
Radiology. 2001 May;219(2):535-40. doi: 10.1148/radiology.219.2.r01ma01535.
To investigate the feasibility of magnetic resonance (MR) flow mapping in the assessment of aortic biophysical properties in patients with Marfan syndrome and to detect differences in biophysical properties in the normal-sized aorta distal to the aortic root between these patients and matched control subjects.
Seventy-eight patients with Marfan syndrome with aortic root dilatation and 23 matched control subjects underwent MR flow mapping in four locations in the normal-sized aorta (1, ascending aorta; 2, thoracic descending aorta; 3, descending aorta at the level of the diaphragm; and 4, abdominal descending aorta). Distensibility at each location and flow wave velocity between locations were calculated.
Compared with the control subjects, patients with Marfan syndrome had decreased aortic distensibility at three of the four locations (levels 1, 2, and 4; P <.05) and increased flow wave velocity between all locations (P <.05) in the aorta. In patients with Marfan syndrome, flow wave velocity was also significantly increased along the entire aortic tract beyond the aortic root (from level 1 to level 4).
MR imaging reveals abnormal biophysical properties of the normal-sized aorta in patients with Marfan syndrome. Monitoring of these properties is relevant for evaluating disease progression and treatment options.
探讨磁共振（MR）血流成像在评估马方综合征患者主动脉生物物理特性中的可行性，并检测这些患者与匹配的对照受试者在主动脉根部远端正常大小主动脉的生物物理特性差异。
78例有主动脉根部扩张的马方综合征患者和23例匹配的对照受试者在正常大小主动脉的四个位置（1，升主动脉；2，胸降主动脉；3，膈肌水平的降主动脉；4，腹降主动脉）接受了MR血流成像。计算每个位置的扩张性以及各位置之间的血流波速度。
与对照受试者相比，马方综合征患者在四个位置中的三个位置（第1、2和4水平；P<.05）主动脉扩张性降低，且主动脉各位置之间的血流波速度增加（P<.05）。在马方综合征患者中，主动脉根部以外的整个主动脉段（从第1水平到第4水平）的血流波速度也显著增加。
MR成像显示马方综合征患者正常大小主动脉的生物物理特性异常。监测这些特性对于评估疾病进展和治疗方案具有重要意义。
