Haringsma J, Tytgat G N, Yano H, Iishi H, Tatsuta M, Ogihara T, Watanabe H, Sato N, Marcon N, Wilson B C, Cline R W
Department of Gastroenterology, Academic Medical Center, Amsterdam, The Netherlands.
Gastrointest Endosc. 2001 May;53(6):642-50. doi: 10.1067/mge.2001.114419.
Case studies are presented of fluorescence endoscopy in the upper and lower GI tract to illustrate the ability to detect early-stage lesions that were not observable with white light endoscopy or those in which the assessment of the stage or extension of the lesion were equivocal.
A new fluorescence imaging system was used in which blue light excites the naturally-occurring fluorescence of tissues (autofluorescence). The system produces real-time, false-color images that combine green and red fluorescence intensities. In general, abnormal lesions are seen to have an increase in the red-to-green fluorescence intensity compared with surrounding tissue. This system was evaluated in patients at 4 participating institutions, concurrently with standard white light endoscopy, with or without dye staining.
Selected cases are presented in which fluorescence imaging identified specific lesions including focal high-grade dysplasia in Barrett's mucosa, signet ring carcinoma of the stomach, and flat adenoma in the colon.
The capability of autofluorescence endoscopy to detect the presence and extent of occult malignant and premalignant GI lesions has been demonstrated. The future development and evaluation of this technology are discussed.
本文展示了上消化道和下消化道荧光内镜检查的病例研究，以说明其检测白光内镜无法观察到的早期病变或病变分期及范围评估不明确的病变的能力。
使用一种新的荧光成像系统，其中蓝光激发组织的天然荧光（自体荧光）。该系统产生结合绿色和红色荧光强度的实时伪彩色图像。一般来说，与周围组织相比，异常病变的红/绿荧光强度会增加。该系统在4个参与机构的患者中进行了评估，同时进行标准白光内镜检查，有无染料染色均可。
展示了一些选定的病例，其中荧光成像识别出了特定病变，包括巴雷特黏膜中的局灶性高级别发育异常、胃印戒细胞癌和结肠扁平腺瘤。
已证明自体荧光内镜能够检测隐匿性恶性和癌前胃肠道病变的存在及范围。讨论了该技术的未来发展和评估。
