Gomes F C, Spohr T C, Martinez R, Moura Neto V
Instituto de Ciências Biomédicas, Departamento de Anatomia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
Braz J Med Biol Res. 2001 May;34(5):611-20. doi: 10.1590/s0100-879x2001000500008.
The development of the nervous system is guided by a balanced action between intrinsic factors represented by the genetic program and epigenetic factors characterized by cell-cell interactions which neural cells might perform throughout nervous system morphogenesis. Highly relevant among them are neuron-glia interactions. Several soluble factors secreted by either glial or neuronal cells have been implicated in the mutual influence these cells exert on each other. In this review, we will focus our attention on recent advances in the understanding of the role of glial and neuronal trophic factors in nervous system development. We will argue that the functional architecture of the brain depends on an intimate neuron-glia partnership.
神经系统的发育由遗传程序所代表的内在因素与表观遗传因素之间的平衡作用所引导，这些表观遗传因素的特征是神经细胞在整个神经系统形态发生过程中可能进行的细胞间相互作用。其中高度相关的是神经元-胶质细胞相互作用。胶质细胞或神经元细胞分泌的几种可溶性因子与这些细胞相互施加的相互影响有关。在这篇综述中，我们将关注在理解胶质细胞和神经元营养因子在神经系统发育中的作用方面的最新进展。我们将论证，大脑的功能结构取决于神经元与胶质细胞之间密切的伙伴关系。
