Zhu Shuang, Yang Bing-Sheng, Li Si-Jing, Tong Ge, Tan Jian-Ye, Wu Guo-Feng, Li Lin, Chen Guo-Li, Chen Qian, Lin Li-Jun
Department of Joint and Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China.
Department of Medical Ultrasonics, Guangdong Province Key Laboratory of Hepatology Research, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.
Neural Regen Res. 2021 Oct;16(10):1935-1943. doi: 10.4103/1673-5374.308068.
Deficits in intrinsic neuronal capacities in the spinal cord, a lack of growth support, and suppression of axonal outgrowth by inhibitory molecules mean that spinal cord injury almost always has devastating consequences. As such, one of the primary targets for the treatment of spinal cord injury is to develop strategies to antagonize extrinsic or intrinsic axonal growth-inhibitory factors or enhance the factors that support axonal growth. Among these factors, a series of individual protein level disorders have been identified during the generation of axons following spinal cord injury. Moreover, an increasing number of studies have indicated that post-translational modifications of these proteins have important implications for axonal growth. Some researchers have discovered a variety of post-translational modifications after spinal cord injury, such as tyrosination, acetylation, and phosphorylation. In this review, we reviewed the post-translational modifications for axonal growth, functional recovery, and neuropathic pain after spinal cord injury, a better understanding of which may elucidate the dynamic change of spinal cord injury-related molecules and facilitate the development of a new therapeutic strategy for spinal cord injury.
脊髓内在神经元能力的缺陷、生长支持的缺乏以及抑制性分子对轴突生长的抑制意味着脊髓损伤几乎总是会产生毁灭性后果。因此，治疗脊髓损伤的主要目标之一是制定策略，以对抗外在或内在的轴突生长抑制因子，或增强支持轴突生长的因子。在这些因素中，在脊髓损伤后轴突生成过程中已经确定了一系列个体蛋白水平的紊乱。此外，越来越多的研究表明，这些蛋白质的翻译后修饰对轴突生长具有重要意义。一些研究人员在脊髓损伤后发现了多种翻译后修饰，如酪氨酸化、乙酰化和磷酸化。在这篇综述中，我们回顾了脊髓损伤后轴突生长、功能恢复和神经性疼痛的翻译后修饰，对其更好的理解可能会阐明脊髓损伤相关分子的动态变化，并促进脊髓损伤新治疗策略的发展。
