Additional bioactive Lyso-PAF congeners from the sponge Spirastrella abata.
作者信息
Alam N, Bae B H, Hong J, Lee C O, Shin B A, Im K S, Jung J H
机构信息
College of Pharmacy, Pusan National University, Pusan 609-735, Korea.
出版信息
J Nat Prod. 2001 Apr;64(4):533-5. doi: 10.1021/np0005210.
PMID:11325244
Abstract
A known (1) and four new (2--5) lyso-PAF (platelet activating factor) derivatives were isolated from the sponge Spirastrella abata. Two of them are unprecedented in having a methoxy group at C-2'. The structures have been determined by combined spectroscopic methods. Their inhibitory effect on the biosynthesis of cholesterol and cytotoxicity against human solid tumor cell lines are reported.
摘要
Zotero 插件