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1
Release of 1-O-alkylglyceryl 3-phosphorylcholine, O-deacetyl platelet-activating factor, from leukocytes: chemical ionization mass spectrometry of phospholipids.1-O-烷基甘油基3-磷酸胆碱（O-脱乙酰基血小板活化因子）从白细胞中的释放：磷脂的化学电离质谱分析
Proc Natl Acad Sci U S A. 1980 Dec;77(12):7019-23. doi: 10.1073/pnas.77.12.7019.
2
Effect of structural analogues of PAF-acether on platelet desensitization.
Br J Haematol. 1983 Mar;53(3):513-21. doi: 10.1111/j.1365-2141.1983.tb02053.x.
3
Specific desensitization of rabbit platelets by platelet-activating factor (PAF-acether) and derivatives.血小板活化因子（PAF-乙酰醚）及其衍生物对兔血小板的特异性脱敏作用。
Br J Haematol. 1982 Jun;51(2):313-22.
4
[Semi-synthesis and proposed structure of platelet-activating factor (P.A.F.): PAF-acether an alkyl ether analog of lysophosphatidylcholine].[血小板激活因子（PAF）的半合成及推测结构：PAF-乙酰乙醚，溶血磷脂酰胆碱的烷基醚类似物]
C R Seances Acad Sci D. 1979 Nov 26;289(14):1037-40.
5
Biosynthesis of platelet-activating factor (PAF-ACETHER). II. Involvement of phospholipase A2 in the formation of PAF-ACETHER and lyso-PAF-ACETHER from rabbit platelets.血小板激活因子（PAF-乙酰醚）的生物合成。II. 磷脂酶A2参与兔血小板中PAF-乙酰醚和溶血PAF-乙酰醚的形成。
Thromb Res. 1982 Mar 1;25(5):375-85. doi: 10.1016/0049-3848(82)90128-1.
6
Dissociation between inhibition of phospholipid methylation and production of PAF-acether by rabbit platelets.兔血小板中磷脂甲基化抑制与血小板活化因子-乙醚生成之间的解离。
Experientia. 1984 Apr 15;40(4):374-7. doi: 10.1007/BF01952560.
7
Platelet-activating factor (PAF-acether), an activator of neutrophil functions.
Agents Actions. 1982 Dec;12(5-6):716-20. doi: 10.1007/BF01965090.
8
Is platelet-activating factor (PAF-acether) synthesis by murine peritoneal cells (PC) a two-step process?
Agents Actions. 1981 Dec;11(6-7):556-8. doi: 10.1007/BF01978738.
9
Synthesis and biological activity of some structural analogs of platelet-activating factor (PAF-acether).血小板活化因子（PAF-乙醚）某些结构类似物的合成及生物活性
Agents Actions. 1981 Dec;11(6-7):558-9. doi: 10.1007/BF01978739.
10
Conversion of 3H-PAF acether by rabbit platelets is independent from aggregation: evidences for a novel metabolite.兔血小板对3H-血小板活化因子乙酰醚的转化与聚集无关：一种新代谢产物的证据。
Biochem Biophys Res Commun. 1983 Feb 10;110(3):890-3. doi: 10.1016/0006-291x(83)91045-8.

引用本文的文献

1
Forty Years Since the Structural Elucidation of Platelet-Activating Factor (PAF): Historical, Current, and Future Research Perspectives.血小板激活因子（PAF）结构阐明四十年来：历史、当前和未来研究视角。
Molecules. 2019 Dec 3;24(23):4414. doi: 10.3390/molecules24234414.
2
Treatment of carrageenan induced arthritis by the platelet activating factor antagonist BN 50730.血小板活化因子拮抗剂BN 50730治疗角叉菜胶诱导的关节炎
Ann Rheum Dis. 1995 Feb;54(2):140-3. doi: 10.1136/ard.54.2.140.
3
Synthesis and biological activity of some structural analogs of platelet-activating factor (PAF-acether).血小板活化因子（PAF-乙醚）某些结构类似物的合成及生物活性
Agents Actions. 1981 Dec;11(6-7):558-9. doi: 10.1007/BF01978739.
4
Release of platelet-activating factor (PAF-acether) and 2-lyso PAF-acether from three cell types.三种细胞类型中血小板活化因子（PAF-乙醚）和2-溶血PAF-乙醚的释放。
Agents Actions. 1982 Dec;12(5-6):711-3. doi: 10.1007/BF01965088.
5
Is platelet-activating factor (PAF-acether) synthesis by murine peritoneal cells (PC) a two-step process?
Agents Actions. 1981 Dec;11(6-7):556-8. doi: 10.1007/BF01978738.
6
Dissociation between inhibition of phospholipid methylation and production of PAF-acether by rabbit platelets.兔血小板中磷脂甲基化抑制与血小板活化因子-乙醚生成之间的解离。
Experientia. 1984 Apr 15;40(4):374-7. doi: 10.1007/BF01952560.
7
Biology and biochemistry of platelet-activating factor.血小板活化因子的生物学与生物化学
Clin Rev Allergy. 1983 Sep;1(3):353-67. doi: 10.1007/BF02991226.
8
Platelet-activating factor stimulates metabolism of phosphoinositides in horse platelets: possible relationship to Ca2+ mobilization during stimulation.血小板活化因子刺激马血小板中磷酸肌醇的代谢：与刺激过程中钙离子动员的可能关系。
Proc Natl Acad Sci U S A. 1983 Feb;80(4):965-8. doi: 10.1073/pnas.80.4.965.
9
Platelet-activating factor (PAF-acether): present status.
Agents Actions. 1981 Dec;11(6-7):542-4. doi: 10.1007/BF01978731.
10
Binding kinetics of PAF-acether (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) to intact human platelets.血小板活化因子（1-O-烷基-2-乙酰基-sn-甘油-3-磷酸胆碱）与完整人血小板的结合动力学
Biochem J. 1984 Nov 1;223(3):901-9. doi: 10.1042/bj2230901.

本文引用的文献

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Release, purification, and characterization of platelet-activating factor (PAF).血小板活化因子（PAF）的释放、纯化及特性鉴定
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A hydrolytic procedure for the identification and estimation of individual phospholipids in biological samples.一种用于鉴定和估算生物样品中单个磷脂的水解方法。
Biochem J. 1960 Apr;75(1):45-53. doi: 10.1042/bj0750045.
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Aliphatic diether analogs of glyceride-derived lipids. 3. Synthesis of dialkenyl and mixed alkylalkenylglycerol ethers.
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Physical studies of phospholipids. IV. High resolution nuclear magnetic resonance spectra of phospholipids and related substances.磷脂的物理研究。IV. 磷脂及相关物质的高分辨率核磁共振谱
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Lipids of human leukocytes: relation to celltype.人类白细胞的脂质：与细胞类型的关系。
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The enzymic synthesis of ethanolamine plasmalogens.乙醇胺缩醛磷脂的酶促合成。
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Platelet-activating factor, a new mediator of anaphylaxis and immune complex deposition from rabbit and human basophils.血小板活化因子，一种来自兔和人嗜碱性粒细胞的过敏反应及免疫复合物沉积的新介质。
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Leukocyte-dependent histamine release from rabbit platelets. The role of IgE, basophils, and a platelet-activating factor.兔血小板中白细胞依赖性组胺释放。IgE、嗜碱性粒细胞和血小板激活因子的作用。
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Destruction of rabbit platelets in the allergic response of sensitized leukocytes. I. Demonstration of a fluid phase intermediate.
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Structural analysis of purified platelet-activating factor by lipases.
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1-O-烷基甘油基3-磷酸胆碱（O-脱乙酰基血小板活化因子）从白细胞中的释放：磷脂的化学电离质谱分析

Release of 1-O-alkylglyceryl 3-phosphorylcholine, O-deacetyl platelet-activating factor, from leukocytes: chemical ionization mass spectrometry of phospholipids.

作者信息

Polonsky J, Tencé M, Varenne P, Das B C, Lunel J, Benveniste J

出版信息

Proc Natl Acad Sci U S A. 1980 Dec;77(12):7019-23. doi: 10.1073/pnas.77.12.7019.

DOI:10.1073/pnas.77.12.7019
PMID:6938950
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC350432/
Abstract

Evidence is presented for the simultaneous release of platelet-activating factor (PAF-acether) and of its deacetylated derivative (lyso-PAF-acether) from hog leukocytes. On the basis of spectroscopy and chemical reactions, the structure of O-deacetyl-PAF is shown to be 1-O-alkylglyceryl 3-phosphorylcholine, an alkyl ether analog of lyso-phosphatidylcholine. Acetylation of lyso-PAF yields a compound with biological activity and chromatographical behavior indistinguishable from those of native PAF. Lyso-PAF may be considered to be either the precursor or the enzymatic degradation product of PAF. The usefulness of chemical ionization mass spectrometry for structural determination of phospholipids is also demonstrated.

摘要

有证据表明，猪白细胞能同时释放血小板活化因子（PAF-乙醚）及其脱乙酰化衍生物（溶血-PAF-乙醚）。基于光谱学和化学反应，O-脱乙酰基-PAF的结构被证明为1-O-烷基甘油基3-磷酸胆碱，即溶血磷脂酰胆碱的烷基醚类似物。溶血-PAF的乙酰化产生一种生物活性和色谱行为与天然PAF无法区分的化合物。溶血-PAF可被认为是PAF的前体或酶促降解产物。还证明了化学电离质谱法在磷脂结构测定中的实用性。