Molina-Hernández M, Téllez-Alcántara N P
Laboratorio de Conducta, Instituto de Investigaciones Psicológicas, Universidad Veracruzana, PO Box 361, CP 91000 Veracruz, Jalapa, Mexico.
Pharmacol Biochem Behav. 2001 Mar;68(3):531-7. doi: 10.1016/s0091-3057(01)00459-2.
Effects of midazolam intraperitoneally (3.0 mg/kg) administered, or locally applied into lateral septal nuclei (10 microg/microl), or into the medial septum (10 microg/microl) were assessed in Wistar rats during late proestrus or metestrus-diestrus in a conflict-operant task. A reduction in conflict behavior was found in control rats during late proestrus (P<.05), when compared to metestrus-diestrus. Systemic injections of midazolam (P<.05) or midazolam infusions into lateral septal nuclei (P<.05) also reduced conflict behavior only during late proestrus, whereas midazolam infusions into the medial septum produced neither of these anticonflict effects in any estrous phase. In conclusion, an endocrine-related variation in anticonflict effects of midazolam microinjected into lateral septal nuclei was displayed by female rats.
在动情后期或动情后期 - 间情期，于一项冲突操作性任务中评估腹腔注射咪达唑仑（3.0毫克/千克）、向外侧隔核局部注射（10微克/微升）或向内侧隔区局部注射（10微克/微升）对Wistar大鼠的影响。与动情后期 - 间情期相比，在动情后期，对照大鼠的冲突行为减少（P<0.05）。全身性注射咪达唑仑（P<0.05）或向外侧隔核注入咪达唑仑（P<0.05）也仅在动情后期减少冲突行为，而向内侧隔区注入咪达唑仑在任何动情期均未产生这些抗冲突效应。总之，雌性大鼠显示出向外侧隔核微量注射咪达唑仑的抗冲突效应存在与内分泌相关的变化。
