Bisignano G, Laganà M G, Trombetta D, Arena S, Nostro A, Uccella N, Mazzanti G, Saija A
Department Farmaco-Biologico, University of Messina, Contrada Annunziata, 98168 Messina, Italy.
FEMS Microbiol Lett. 2001 Apr 20;198(1):9-13. doi: 10.1111/j.1574-6968.2001.tb10611.x.
In the present paper we report the 'in vitro' activity of eight aliphatic long-chain aldehydes from olive flavor (hexanal, nonanal, (E)-2-hexenal, (E)-2-eptenal, (E)-2-octenal, (E)-2-nonenal, (E)-2-decenal and (E,E)-2,4-decadienal) against a number of standard and freshly isolated bacterial strains that may be causal agents of human intestinal and respiratory tract infections. The saturated aldehydes characterized in the present study do not exhibit significant antibacterial activity, while the alpha,beta-unsaturated aldehydes have a broad antimicrobial spectrum and show similar activity against Gram-positive and Gram-negative microorganisms. The effectiveness of the aldehydes under investigation seems to depend not only on the presence of the alpha,beta-double bond, but also on the chain length from the enal group and on the microorganism tested.
在本论文中,我们报告了来自橄榄风味的八种脂肪族长链醛(己醛、壬醛、(E)-2-己烯醛、(E)-2-庚烯醛、(E)-2-辛烯醛、(E)-2-壬烯醛、(E)-2-癸烯醛和(E,E)-2,4-癸二烯醛)对一些可能是人类肠道和呼吸道感染病原体的标准菌株及新分离菌株的“体外”活性。本研究中表征的饱和醛不表现出显著的抗菌活性,而α,β-不饱和醛具有广泛的抗菌谱,并且对革兰氏阳性和革兰氏阴性微生物表现出相似的活性。所研究醛类的有效性似乎不仅取决于α,β-双键的存在,还取决于烯醛基团的链长以及所测试的微生物。