Vijakumaran Ubashini, Goh Neng-Yao, Razali Rabiatul Adawiyah, Abdullah Nur Atiqah Haizum, Yazid Muhammad Dain, Sulaiman Nadiah
Centre for Tissue Engineering & Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, Kuala Lumpur 56000, Malaysia.
Antioxidants (Basel). 2023 May 23;12(6):1140. doi: 10.3390/antiox12061140.
Respiratory diseases recently became the leading cause of death worldwide, due to the emergence of COVID-19. The pathogenesis of respiratory diseases is centred around inflammation and oxidative stress. Plant-based alongside synthetic drugs were considered as therapeutics due to their proven nutraceutical value. One such example is the olive, which is a traditional symbol of the MedDiet. Olive bioactive compounds are enriched with antioxidant, anti-inflammatory, anticancer and antiviral properties. However, there are few studies relating to the beneficial effect of olive bioactive compounds on respiratory diseases. A vague understanding of its molecular action, dosage and bioavailability limits its usefulness for clinical trials about respiratory infections. Hence, our review aims to explore olive bioactive compound's antioxidant, anti-inflammatory and antiviral properties in respiratory disease defence and treatment. Molecular insight into olive compounds' potential for respiratory system protection against inflammation and ensuing infection is also presented. Olive bioactive compounds mainly protect the respiratory system by subsiding proinflammatory cytokines and oxidative stress.
由于新冠病毒的出现，呼吸系统疾病最近成为全球主要死因。呼吸系统疾病的发病机制以炎症和氧化应激为核心。基于植物的药物以及合成药物因其已被证实的营养保健价值而被视为治疗手段。其中一个例子就是橄榄，它是地中海饮食的传统象征。橄榄生物活性化合物富含抗氧化、抗炎、抗癌和抗病毒特性。然而，关于橄榄生物活性化合物对呼吸系统疾病有益作用的研究很少。对其分子作用、剂量和生物利用度的模糊认识限制了其在呼吸道感染临床试验中的应用。因此，我们的综述旨在探讨橄榄生物活性化合物在呼吸道疾病防御和治疗中的抗氧化、抗炎和抗病毒特性。本文还介绍了对橄榄化合物保护呼吸系统免受炎症及后续感染潜力的分子见解。橄榄生物活性化合物主要通过减轻促炎细胞因子和氧化应激来保护呼吸系统。
