Schmidt S M, Müller C E, Krechting M, Wiersbitzky H, Gürtler L, Wiersbitzky S K W
Dept. of Infectious, Bronchopulmonary and Allergic Diseases, Children's and Youth Hospital, Soldmannstr. 15, D-17487 Greifswald, Germany.
Infection. 2003 Dec;31(6):410-6. doi: 10.1007/s15010-003-3159-5.
The importance of Chlamydia pneumoniae respiratory tract infection in childhood is under discussion.
798 hospitalized children with respiratory tract diseases were prospectively studied during a 2-year period by polymerase chain reaction and enzyme immunoassay (PCR-EIA) detection from throat swabs. Paired serum samples were used to screen for Chlamydia antibodies.
C. pneumoniae was detected by PCR-EIA in 74 children. Prevalence was 11% in lower and 4% in upper respiratory tract disease (p = 0.049) without age dependency. From November to February prevalence was elevated (42/277 vs. 32/521; p < 0.001). Using serology, prevalence of acute Chlamydia infection increased with age (p < 0.001) and the number of coinfections (p < 0.001), without seasonal variation.
Characteristics of C. pneumoniae carriage in the respiratory tract in childhood differ from those in systemic infection.
肺炎衣原体呼吸道感染在儿童时期的重要性仍在讨论中。
对798例呼吸道疾病住院儿童进行了为期2年的前瞻性研究，通过聚合酶链反应和酶免疫测定（PCR-EIA）从咽拭子中进行检测。采用配对血清样本筛查衣原体抗体。
通过PCR-EIA在74例儿童中检测到肺炎衣原体。下呼吸道疾病患病率为11%，上呼吸道疾病患病率为4%（p = 0.049），与年龄无关。11月至2月患病率升高（42/277 vs. 32/521；p < 0.001）。采用血清学检测，急性衣原体感染患病率随年龄增长（p < 0.001）和合并感染数量增加（p < 0.001），无季节性变化。
儿童呼吸道肺炎衣原体携带特征与全身感染不同。
