Katz A S, Goff D C, Feldman S R
Department of Dermatology Wake Forest University School of Medicine, USA.
Dermatol Online J. 2000 Sep;6(1):1.
Acanthosis nigricans is traditionally characterized by hyperpigmented, velvety plaques of body folds. Involvement of other areas occurs as well. The condition is caused by hyperinsulinemia, a consequence of insulin resistance that occurs associated with obesity. As the frequency and degree of obesity increase in the population, a concomitant increase in acanthosis nigricans can be expected. The dermatologist has an important role in identifying the subset of obese patients with acanthosis nigricans. These patients have hyperinsulinemia and may be at greater risk of consequent atherosclerotic cardiovascular disease. It is essential for dermatologists to recognize the many presentations of acanthosis nigricans to identify patients at risk for associated medical conditions. This article illustrates a variety of presentations of acanthosis nigricans associated with insulin resistance.
黑棘皮病传统上的特征是身体褶皱处出现色素沉着、天鹅绒样斑块。其他部位也会受累。这种情况是由高胰岛素血症引起的，高胰岛素血症是肥胖相关的胰岛素抵抗的结果。随着人群中肥胖的发生率和程度增加，可以预期黑棘皮病也会随之增加。皮肤科医生在识别患有黑棘皮病的肥胖患者亚组方面发挥着重要作用。这些患者存在高胰岛素血症，可能发生动脉粥样硬化性心血管疾病的风险更高。皮肤科医生必须认识到黑棘皮病的多种表现形式，以识别有相关疾病风险的患者。本文阐述了与胰岛素抵抗相关的黑棘皮病的多种表现。
