Gynecologic Endocrinology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Int J Endocrinol. 2012;2012:529184. doi: 10.1155/2012/529184. Epub 2012 Jan 12.
Objectives. To determine the prevalence of insulin resistance (IR) and its predictors in reproductive-aged Thai women with polycystic ovary syndrome (PCOS). Methods. A cross-sectional study was conducted from May 2007 to January 2009. Participants were 250 Thai women with PCOS. Information regarding medical history and physical examination and results of 75 gram OGTT were recorded. Results. The overall prevalence of IR was 20.0%, comprising the prevalence of impaired fasting glucose, impaired glucose tolerance, and diabetic mellitus of 3.2%, 13.6%, and 5.6%, respectively. Multiple logistic regression analysis showed that the independent predictors for IR were age of ≥30 years old, waist circumference (WC) of ≥80 cm, presence of acanthosis nigricans (AN), and dyslipidemia with odds ratios (95% confidence interval) of 2.14 (1.01-4.52), 3.53 (1.28-9.75), 2.63 (1.17-5.88), and 3.07 (1.16-8.11), respectively. Conclusion. The overall prevalence of IR in reproductive-aged Thai women with PCOS is 20.0%. Age ≥30 years old, WC ≥80 cm, the presence of AN, and dyslipidemia are the significant clinical predictors.
目的。确定患有多囊卵巢综合征（PCOS）的泰国育龄期妇女胰岛素抵抗（IR）的流行率及其预测因素。方法。一项横断面研究于 2007 年 5 月至 2009 年 1 月进行。参与者为 250 名泰国 PCOS 女性。记录了有关病史、体格检查和 75 克 OGTT 结果的信息。结果。IR 的总体患病率为 20.0％，包括空腹血糖受损、葡萄糖耐量受损和糖尿病的患病率分别为 3.2％、13.6％和 5.6％。多因素逻辑回归分析显示，IR 的独立预测因素为年龄≥30 岁、腰围（WC）≥80cm、存在黑棘皮病和血脂异常，其比值比（95％置信区间）分别为 2.14（1.01-4.52）、3.53（1.28-9.75）、2.63（1.17-5.88）和 3.07（1.16-8.11）。结论。患有 PCOS 的泰国育龄期妇女的 IR 总体患病率为 20.0％。年龄≥30 岁、WC≥80cm、存在 AN 和血脂异常是重要的临床预测因素。
