Zarantonelli L, Borthagaray G, Lee E H, Veal W, Shafer W M
National Center for Gonococcal Antimicrobial Susceptibility Surveillance, Department of Microbiology, School of Chemistry, Avda Gral Flores 2124, Montevideo 11800, Uruguay.
J Antimicrob Chemother. 2001 May;47(5):651-4. doi: 10.1093/jac/47.5.651.
During a screen of Neisseria gonorrhoeae clinical isolates obtained in Uruguay for susceptibility to azithromycin, we noticed that approximately 10% of the strains examined displayed decreased susceptibility to azithromycin and erythromycin due to the mtr(CDE)-encoded efflux pump system, but remained susceptible to Triton X-100. We now report that the mtr(R) promoter region of one of these isolates contains a dinucleotide insertion (TT) that mediates this resistance phenotype.
在对从乌拉圭获得的淋病奈瑟菌临床分离株进行阿奇霉素敏感性筛查期间，我们注意到，由于mtr（CDE）编码的外排泵系统，所检测的菌株中约有10%对阿奇霉素和红霉素的敏感性降低，但对 Triton X - 100仍敏感。我们现在报告，其中一株分离株的mtr（R）启动子区域含有一个二核苷酸插入（TT），该插入介导了这种耐药表型。
