短小棒状杆菌对不同品系小鼠针对绵羊红细胞应答所产生抗体的类别和亚类的影响。
Effect of Corynebacterium parvum on the class and subclass of antibody produced in the response of different strains of mice to sheep erythrocytes.
作者信息
Warr G W, James K
出版信息
Immunology. 1975 Mar;28(3):431-42.
Abstract
Several strains of mice were injected with sheep erythrocytes (SRBC) using C. parvum as adjuvant. The adjuvant effects on the amounts of class and subclass of antibody produced were ranked in the order IgG2b greater than IgG2a and IgM greater than IgG1. In addition, these effects were shown to vary depending on the time of administration of C. parvum relative to antigen. C parvum was shown to have no adjuvant effect on the response of congenitally athymic mice when given at the same time as the antigen, SRBC. On the basis of the reported observations it is suggested that certain of the adjuvant effects of C. parvum require T-cell function.
摘要
使用微小隐孢子虫作为佐剂，给几株小鼠注射绵羊红细胞（SRBC）。对所产生抗体的类别和亚类数量的佐剂效应按以下顺序排列：IgG2b大于IgG2a，IgM大于IgG1。此外，这些效应显示会因微小隐孢子虫相对于抗原的给药时间而异。当与抗原SRBC同时给药时，微小隐孢子虫对先天性无胸腺小鼠的反应没有佐剂效应。根据所报道的观察结果，提示微小隐孢子虫的某些佐剂效应需要T细胞功能。
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本文引用的文献
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