Katevuo K, Kanto J, Pihlajamäki K
Invest Radiol. 1975 May-Jun;10(3):197-9. doi: 10.1097/00004424-197505000-00002.
In a double blind study 45 patients were given either an i.v. injection of 20 mg Primperan (20 mg metoclopramide, Lundbeck, n = 15), 20 mg Metopram (20 mg metoclopramide, Leiras, n = 15) or a corresponding amount of physiological saline (n = 15) and the effect of metoclopramide on the human gallbladder was studied in x-ray examination of gallbladder. The gallstones do not appear to be a contraindication for the clinical use of metoclopramide as an antiemetic drug. No contraction of the gallbladder was demonstrated, even though metoclopramide has been shown to contact intestinal smooth muscle. Primperan caused more side effects than Metopram. Sedation seems to be the most common side effect of metoclopramide.
在一项双盲研究中，45名患者分别接受静脉注射20毫克普瑞博思（20毫克甲氧氯普胺，伦贝克公司生产，n = 15）、20毫克美托普胺（20毫克甲氧氯普胺，莱拉斯公司生产，n = 15）或相应剂量的生理盐水（n = 15），并通过胆囊X光检查研究甲氧氯普胺对人体胆囊的影响。胆结石似乎并非临床使用甲氧氯普胺作为止吐药的禁忌证。尽管甲氧氯普胺已被证明可使肠道平滑肌收缩，但未显示胆囊有收缩。普瑞博思比美托普胺引起的副作用更多。镇静似乎是甲氧氯普胺最常见的副作用。
