Blahová J, Králiková K, Krcméry V, Kubonová K, Vaculíková A, Mikovicová A, Klokocníková L, Hanzen J, Jezek P
Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic.
J Chemother. 2001 Apr;13(2):143-7. doi: 10.1179/joc.2001.13.2.143.
Sixty-seven multiresistant nosocomial Acinetobacter baumannii isolates from patients hospitalized mostly in intensive care units of seven clinics in Slovak and Czech Republic were tested to determine their ability to transfer antibiotic resistance. All isolates were resistant to kanamycin, ticarcillin, cephalothin, cefotaxime, ceftazidime, aztreonam and susceptible to carbapenems, sulbactam and ampicillin/sulbactam. Sixty-five out of 67 strains transferred resistance determinants to Escherichia coli K-12 and Proteus mirabilis P-38 recipients. Analysis of selected transconjugants by an indirect selection method showed a more variable pattern of transferred resistance determinants. The clonal spread of strains transferring resistance seems to be an additional risk for occurrence of strains resistant to ceftazidime and aztreonam.
对来自斯洛伐克和捷克共和国七家诊所重症监护病房住院患者的67株多重耐药医院鲍曼不动杆菌分离株进行了测试，以确定它们转移抗生素耐药性的能力。所有分离株对卡那霉素、替卡西林、头孢噻吩、头孢噻肟、头孢他啶、氨曲南耐药，对碳青霉烯类、舒巴坦和氨苄西林/舒巴坦敏感。67株菌株中有65株将耐药决定因子转移至大肠杆菌K-12和奇异变形杆菌P-38受体菌。通过间接选择法对选定的接合子进行分析，结果显示转移的耐药决定因子模式更为多样。转移耐药性的菌株的克隆传播似乎是出现对头孢他啶和氨曲南耐药菌株的额外风险。
