Blahová J, Králiková K, Krćméry V, Vaculíková A, Jezek P
Institute of Preventive and Clinical Medicine, Limbová 14, 833 01 Bratislava, Slovak Republic.
J Chemother. 2002 Oct;14(5):461-4. doi: 10.1179/joc.2002.14.5.461.
The occurrence of positive synergy between antibiotic discs of amoxicillin/clavulanate and cefoperazone was registered in two Klebsiella pneumoniae strains, isolated from hospitals in Czech and Slovak Republic, indicating the presence of genes coding for an extended-spectrum beta-lactamase active also against cefoperazone, a broad-spectrum cephalosporin. Sulbactam inhibited the hydrolysis of cefoperazone by cell-free lysates of these strains which substantiates its use in combination with cefoperazone. Resistance to cephalothin, cefotaxime, ceftazidime, cefoperazone, cefepime and aztreonam was transferred from K. pneumoniae isolates to Escherichia coli K-12 3110 and to Proteus mirabilis P-38 recipient strains.
在从捷克和斯洛伐克共和国医院分离出的两株肺炎克雷伯菌中，记录到阿莫西林/克拉维酸和头孢哌酮的抗生素纸片之间出现了正协同作用，这表明存在编码对广谱头孢菌素头孢哌酮也有活性的超广谱β-内酰胺酶的基因。舒巴坦抑制了这些菌株的无细胞裂解物对头孢哌酮的水解，这证实了其与头孢哌酮联合使用的合理性。对头孢噻吩、头孢噻肟、头孢他啶、头孢哌酮、头孢吡肟和氨曲南的耐药性从肺炎克雷伯菌分离株转移到了大肠杆菌K-12 3110和奇异变形杆菌P-38受体菌株。
