Blahová J, Králiková K, Krcméry V, Chmelarová E, Torsová V
Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic.
J Chemother. 1998 Feb;10(1):22-4. doi: 10.1179/joc.1998.10.1.22.
In this report we describe a specific transfer of carbenicillin and cephaloridine resistance determinants from two different strains of Stenotrophomonas maltophilia: No. 215 and 221 isolated from two critically ill patients treated in different Intensive Care Units of a large University Hospital in Ostrava, Czech Republic. These strains were resistant to flouroquinolones and the following beta-lactam drugs: carbenicillin, cephaloridine, cefotaxime, ceftazidime, cefepime, imipenem, meropenem and aztreonam. Both strains transferred carbenicillin and cephaloridine resistance determinants, with rather different frequency, to Proteus mirabilis P-38. All carbenicillin-selected transconjugants were found by an indirect selection method to be co-resistant to cephaloridine only. In a second cycle of transfers Proteus mirabilis R+ strains directly transferred carbenicillin and cephalothin determinants to Escherichia coli K-12 No. 185 nal+ lac+ recipient strain.
在本报告中，我们描述了从嗜麦芽窄食单胞菌的两个不同菌株（编号215和221，从捷克共和国俄斯特拉发市一家大型大学医院不同重症监护病房接受治疗的两名重症患者中分离得到）中特异性转移羧苄青霉素和头孢菌素耐药决定簇的情况。这些菌株对氟喹诺酮类药物以及以下β-内酰胺类药物耐药：羧苄青霉素、头孢菌素、头孢噻肟、头孢他啶、头孢吡肟、亚胺培南、美罗培南和氨曲南。这两个菌株以相当不同的频率将羧苄青霉素和头孢菌素耐药决定簇转移至奇异变形杆菌P-38。通过间接选择法发现，所有羧苄青霉素选择的接合子仅对头孢菌素共耐药。在第二轮转移中，奇异变形杆菌R+菌株将羧苄青霉素和头孢噻吩决定簇直接转移至大肠杆菌K-12 185号nal+ lac+受体菌株。
