Enhanced anti-cancer activities of some derivatives of titanocene dichloride.
作者信息
Boyles J R, Bair M C, Campling B G, Jain N
机构信息
Department of Chemistry, Queen's University, Kingston, Canada.
出版信息
J Inorg Biochem. 2001 Mar;84(1-2):159-62. doi: 10.1016/s0162-0134(00)00203-8.
Abstract
The compounds (eta5-C5H5)2TiCl2 (I), currently undergoing phase II trials, (eta5-C5H5)(eta5-C5H4CO2Me)TiCl2 (II) and C5H4CO2Me)2TiCl2 (III) are assessed for their efficacies against a small lung cancer cell line. It is found that the introduction of the electron withdrawing carbomethoxy group into the cyclopentadienyl rings increases the effectiveness of this class of drugs, such that III compares favorably with the well known cisplatin.
摘要
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