法替韦拉辛FV-8对1型人类免疫缺陷病毒（HIV-1）的抗病毒活性。
Antiviral activity of fattiviracin FV-8 against human immunodeficiency virus type 1 (HIV-1).
作者信息
Habib E S, Yokomizo K, Nagao K, Harada S, Uyeda M
机构信息
Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
出版信息
Biosci Biotechnol Biochem. 2001 Mar;65(3):683-5. doi: 10.1271/bbb.65.683.
A novel antiviral agent, fattiviracin FV-8, purified from the culture broth of Streptomyces microflavus strain No. 2445, showed potent antiviral activities against human immunodeficiency virus type 1 (HIV-1), herpes simplex virus type 1 (HSV-1), varicella-zoster virus (VZV), and influenza A and B viruses. The action mechanism of fattiviracin FV-8 against HIV-1 was examined. As a result, the agent was thought to act on HIV-1 particles directly without lysis of the particles, and it affords the inhibition of viral entry into the host cells.
一种从微小黄色链霉菌2445号菌株的培养液中纯化得到的新型抗病毒剂法替韦拉辛FV - 8，对1型人类免疫缺陷病毒（HIV - 1）、1型单纯疱疹病毒（HSV - 1）、水痘 - 带状疱疹病毒（VZV）以及甲型和乙型流感病毒显示出强大的抗病毒活性。研究了法替韦拉辛FV - 8对HIV - 1的作用机制。结果表明，该药剂被认为是直接作用于HIV - 1颗粒而不使颗粒裂解，并能抑制病毒进入宿主细胞。
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