Hayashi K, Kamiya M, Hayashi T
Department of Virology, Toyama Medical and Pharmaceutical University, Japan.
Planta Med. 1995 Jun;61(3):237-41. doi: 10.1055/s-2006-958063.
The steam distillate prepared from fresh plants of Houttuynia cordata Thunb. (Saururaceae) was found to have direct inhibitory activity against herpes simplex virus type 1 (HSV-1), influenza virus, and human immunodeficiency virus type 1 (HIV-1) without showing cytotoxicity, but not against poliovirus and coxsackie-virus. The loss of viral infectivity was related to the duration of drug treatment. Three major components of the distillate, methyl n-nonyl ketone, lauryl aldehyde, and capryl aldehyde, also inactivated HSV-1, influenza virus, and HIV-1. These in vitro findings demonstrate that the essential oils provide virucidal activity against enveloped viruses by interfering with the function of virus envelope.
从新鲜的蕺菜（三白草科）植株制备的水蒸气蒸馏液被发现对1型单纯疱疹病毒（HSV-1）、流感病毒和1型人类免疫缺陷病毒（HIV-1）具有直接抑制活性，且不显示细胞毒性，但对脊髓灰质炎病毒和柯萨奇病毒无抑制作用。病毒感染性的丧失与药物处理的持续时间有关。蒸馏液的三种主要成分，正壬基甲基酮、月桂醛和辛酸醛，也能使HSV-1、流感病毒和HIV-1失活。这些体外研究结果表明，精油通过干扰病毒包膜的功能对包膜病毒具有杀病毒活性。
