Cuschieri A, Bannister L H
J Anat. 1975 Apr;119(Pt 2):277-86.
The development of the olfactory and vomeronasal epithelia of the mouse has been investigated from the 9th day of gestation until shortly after birth. On the 10th day axons emerge from the base of the olfactory epithelium to reach the olfactory bulb primordia on the 11th day, at which time the olfactory dendrites first appear. On the 13th day a distinction between the elongate nuclei of the embryonic stem cells and the rounded nuclei of the differentiating receptors is visible. A basal layer of stem cells remains mitotically active from the 13th day of gestation onwards, and after the 15th day the majority of mitoses occur in this layer. It is suggested that from the 15th day of gestation onwards the nuclei situated most apically become those of the supporting cells. The glands of Bowman are first visible on the 17th day of gestation. The diverticulum of the vomeronasal organ begins to form on the 11th day and the development of its sensory epithelium resembles that of the olfactory organ except for the absence of basally situated stem cell nuclei in the later stages of the vomeronasal organ.
从妊娠第9天到出生后不久，对小鼠嗅觉上皮和犁鼻上皮的发育进行了研究。在第10天，轴突从嗅觉上皮基部发出，在第11天到达嗅球原基，此时嗅觉树突首次出现。在第13天，可以看到胚胎干细胞的细长核与分化受体的圆形核之间的区别。从妊娠第13天起，干细胞的基底层保持有丝分裂活性，在第15天后，大多数有丝分裂发生在该层。有人认为，从妊娠第15天起，最顶端的核变成支持细胞的核。鲍曼腺在妊娠第17天首次可见。犁鼻器憩室在第11天开始形成，其感觉上皮的发育与嗅觉器官相似，只是在犁鼻器后期没有位于基部的干细胞核。
