Wiersma T J, Timmermans A E
Nederlands Huisartsen Genootschap, afd. Standaardenontwikkeling, Postbus 3231, 3502 GE Utrecht.
Ned Tijdschr Geneeskd. 2001 Apr 14;145(15):735-9.
The important changes in the Dutch College of General Practitioners' revised guideline on urinary tract infections, with respect to the first edition, are as follows: In assessing a urine sediment the leucocyte count has been omitted due to its low specificity. In the case of a negative nitrite test, the number of bacteria is of diagnostic importance. If a microscopic count is difficult to carry out, a semi-quantitative culture with a dip-slide is a good alternative. In the case of uncomplicated urinary tract infections, nitrofurantoin or trimethoprim are the preferred antibiotics, whereas for pregnant women nitrofurantoin and amoxicillin without clavulanic acid should be used. The most important pathogen is often resistant to sulphonamides. In the case of complicated urinary tract infections, characterised by fever, and a still unknown sensitivity of the pathogen, amoxicillin-clavulanic acid is recommended except in the case of pregnant women. The usefulness of tracing and treating pregnant women with asymptomatic bacteriuria has yet to be demonstrated.
在评估尿沉渣时,由于白细胞计数特异性低,已将其省略。在亚硝酸盐试验为阴性的情况下,细菌数量具有诊断意义。如果难以进行显微镜计数,使用浸片进行半定量培养是一个很好的替代方法。对于单纯性尿路感染,呋喃妥因或甲氧苄啶是首选抗生素,而对于孕妇应使用呋喃妥因和不含克拉维酸的阿莫西林。最重要的病原体通常对磺胺类药物耐药。对于以发热为特征且病原体敏感性仍未知的复杂性尿路感染,除孕妇外,推荐使用阿莫西林-克拉维酸。追踪和治疗无症状菌尿的孕妇的有效性尚未得到证实。