Agudelo C A, Wise C M
Rheumatology Section, Emory University School of Medicine, and Atlanta Veterans Affairs Medical Center, Decatur, Georgia, USA.
Curr Opin Rheumatol. 2001 May;13(3):234-9. doi: 10.1097/00002281-200105000-00015.
Gout is a common form of arthritis, in which many of the risk factors, pathogenetic mechanisms, and clinical features have been recognized for years. Nevertheless, new information has become available regarding the normal physiologic role of uric acid as an antioxidant, and greater insight has been obtained regarding the inflammatory process in acute gout. New studies have improved our understanding of the role of genetic and environmental factors responsible for hyperuricemia, and we know more about the significance of the association of hyperuricemia with other diseases. Clinically, rare complications and disease manifestations in new populations continue to be discussed, and diagnostic methods continue to be refined.
痛风是一种常见的关节炎形式，多年来人们已经认识到其中许多风险因素、发病机制和临床特征。然而，关于尿酸作为抗氧化剂的正常生理作用，已有新的信息出现，并且对于急性痛风的炎症过程也有了更深入的了解。新的研究增进了我们对导致高尿酸血症的遗传和环境因素作用的理解，而且我们对高尿酸血症与其他疾病关联的重要性也有了更多认识。在临床上，新人群中的罕见并发症和疾病表现仍在持续讨论中，诊断方法也在不断完善。
