信函：一类新型强效鸟嘌呤抗代谢物。通过咪唑前体的新型环化反应合成3-脱氮鸟嘌呤、3-脱氮鸟苷和3-脱氮鸟苷酸。 - Suppr | 超能文献

Letter: A new class of potent guanine antimetabolites. Synthesis of 3-deazaguanine, 3-deazaguanosine, and 3-deazaguanylic acid by a novel ring closure of imidazole precursors.

作者信息

Cook P D, Rousseau R J, Mian A M, Meyer R B, Dea P, Ivanovics G

出版信息

J Am Chem Soc. 1975 May 14;97(10):2916. doi: 10.1021/ja00843a059.

DOI:10.1021/ja00843a059

Abstract

摘要

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Letter: A new class of potent guanine antimetabolites. Synthesis of 3-deazaguanine, 3-deazaguanosine, and 3-deazaguanylic acid by a novel ring closure of imidazole precursors.信函：一类新型强效鸟嘌呤抗代谢物。通过咪唑前体的新型环化反应合成3-脱氮鸟嘌呤、3-脱氮鸟苷和3-脱氮鸟苷酸。

J Am Chem Soc. 1975 May 14;97(10):2916. doi: 10.1021/ja00843a059.

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Synthesis of 3-deazaguanine, 3-deazaguanosine, and 3-deazaguanylic acid by a novel ring closure of imidazole precursors.通过咪唑前体的新型环化反应合成3-脱氮鸟嘌呤、3-脱氮鸟苷和3-脱氮鸟苷酸。

J Am Chem Soc. 1976 Mar 17;98(6):1492-8. doi: 10.1021/ja00422a036.

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[The use in medicine of guanine compounds and the methods for their production].

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Synthesis and antiviral/antitumor activities of certain 3-deazaguanine nucleosides and nucleotides.某些3-脱氮鸟嘌呤核苷和核苷酸的合成及其抗病毒/抗肿瘤活性

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Effects of 3-deazaguanosine and 3-deazaguanine on the growth and maturation of the human promyelocytic leukemia cell line, HL-60.3-去氮鸟苷和3-去氮鸟嘌呤对人早幼粒细胞白血病细胞系HL-60生长和成熟的影响

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The metabolism of 3-deazaguanine and 3-deazaguanosine by human cells in culture.人培养细胞对3-脱氮鸟嘌呤和3-脱氮鸟苷的代谢

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Comparative study by circular dichroism of the conformation of deazapurine nucleosides and that of common purine nucleosides.通过圆二色性对脱氮嘌呤核苷与常见嘌呤核苷构象的比较研究。

Proc Natl Acad Sci U S A. 1976 Jul;73(7):2384-7. doi: 10.1073/pnas.73.7.2384.