3-脱氮鸟嘌呤、3-脱氮鸟苷和3-脱氮鸟苷酸的抗病毒活性。
Antiviral activity of 3-deazaguanine, 3-deazaguanosine, and 3-deazaguanylic acid.
作者信息
Allen L B, Huffman J H, Dan Cook P, Meyer R B, Robins R K, Sidwell R W
出版信息
Antimicrob Agents Chemother. 1977 Jul;12(1):114-9. doi: 10.1128/AAC.12.1.114.
Abstract
3-Deazaguanine (ICN 4221), 3-deazaguanosine (ICN 4793), and 3-deazaguanylic acid (ICN 5412) represent a new class of synthetic guanine analogs having antiviral activity. In vitro, nine ribonucleic acid and seven deoxyribonucleic acid viruses were inhibited, including influenza, parainfluenza, rhino-, vesicular stomatitis, adeno-, herpes-, cytomegalo-, vaccinia, pseudorabies, and myxoma viruses. They were effective orally against influenza types A and B and parainfluenza type 1 (Sendai) virus infections in mice, with a therapeutic index of 16 against the latter two viruses. The course of herpes encephalitis was altered only when the drugs were applied directly into the brain. In addition, these drugs were effective inhibitors of Friend leukemia virus-induced splenomegaly in mice; treatment also produced extensions of life in these animals.
摘要
3-脱氮鸟嘌呤（ICN 4221）、3-脱氮鸟苷（ICN 4793）和3-脱氮鸟苷酸（ICN 5412）代表了一类具有抗病毒活性的新型合成鸟嘌呤类似物。在体外，九种核糖核酸病毒和七种脱氧核糖核酸病毒受到抑制，包括流感病毒、副流感病毒、鼻病毒、水疱性口炎病毒、腺病毒、疱疹病毒、巨细胞病毒、痘苗病毒、伪狂犬病病毒和黏液瘤病毒。它们口服对小鼠的甲型和乙型流感病毒以及1型副流感病毒（仙台病毒）感染有效，对后两种病毒的治疗指数为16。仅当药物直接注入脑内时，疱疹性脑炎的病程才会改变。此外，这些药物是小鼠中Friend白血病病毒诱导的脾肿大的有效抑制剂；治疗还延长了这些动物的寿命。
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