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ABO和Rh系统基因多态性与支气管哮喘的关系:初步报告

Genetic polymorphism of ABO and Rh system in relation to bronchial asthma: preliminary report.

作者信息

De la Vega A R, Gómez Cortés J, Bacallao Gallestey J

出版信息

Allergol Immunopathol (Madr). 1976 Sep-Oct;4(5):305-10.

PMID:827205
Abstract

115 asthmatic children and 1001 healthy voluntary blood donors were studied in order to determine the distribution of blood groups among them. Gene frequencies were also calculated in asthmatic patients and controls. No difference was noted between Rh system in both groups; but the ABO system showed an excess of blood group A among asthmatic patients. Gene frequency of A (p) and gene frequency of O (r) was quite different too for asthmatics and controls. No difference was noted in blood groups B and AB; nor in the gene frequency of B(q). The difference in the distribution of blood group A and O between control and asthmatic groups was found to be highly significant (P less than 0.02) with the chi-square test.

摘要

为了确定115名哮喘儿童和1001名健康自愿献血者的血型分布情况,对他们进行了研究。同时也计算了哮喘患者和对照组的基因频率。两组的Rh系统未发现差异;但ABO系统显示哮喘患者中A型血比例过高。哮喘患者和对照组的A基因频率(p)和O基因频率(r)也有很大差异。B型和AB型血以及B基因频率(q)在两组中均未发现差异。通过卡方检验发现,对照组和哮喘组之间A型和O型血分布的差异具有高度显著性(P小于0.02)。

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Hum Genet. 1979 Jul 18;49(3):337-48. doi: 10.1007/BF00569354.