鼠柠檬酸杆菌与传染性小鼠结肠增生的分子发病机制。
Molecular pathogenesis of Citrobacter rodentium and transmissible murine colonic hyperplasia.
作者信息
Luperchio S A, Schauer D B
机构信息
Division of Bioengineering and Environmental Health, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room 56-787B, Cambridge, Massachusetts 02139, USA.
出版信息
Microbes Infect. 2001 Apr;3(4):333-40. doi: 10.1016/s1286-4579(01)01387-9.
Here we review the history, clinical significance, pathology and molecular pathogenesis of Citrobacter rodentium, the causative agent of transmissible murine colonic hyperplasia. C. rodentium serves as an important model pathogen for investigating the mechanisms controlling attaching and effacing pathology, epithelial hyperproliferation, and tumor promotion in the distal colon of the mouse.
在此，我们综述了鼠柠檬酸杆菌（可传播性小鼠结肠增生的病原体）的历史、临床意义、病理学及分子发病机制。鼠柠檬酸杆菌是研究小鼠远端结肠中控制紧密黏附性病理改变、上皮细胞过度增殖及肿瘤促进机制的重要模式病原体。
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