Schauer D B, Falkow S
Department of Microbiology and Immunology, Stanford University School of Medicine, California 94305-5402.
Infect Immun. 1993 Nov;61(11):4654-61. doi: 10.1128/iai.61.11.4654-4661.1993.
Transmissible murine colonic hyperplasia is characterized by proliferation of anchored stem cells in the mucosa of the descending colon of laboratory mice and is caused by Citrobacter freundii biotype 4280. This bacterium produces attaching and effacing lesions in the descending colon prior to the onset of gross hyperplasia. By mutational analysis, the chromosomal eae gene of C. freundii biotype 4280 was shown to be necessary for colonic colonization. Conversely, bacteria cured of a 65-kb plasmid, which was identified in C. freundii biotype 4280, were not attenuated for colonic colonization or for the induction of colonic hyperplasia.
可传播性小鼠结肠增生的特征是实验室小鼠降结肠黏膜中锚定干细胞的增殖，由弗氏柠檬酸杆菌生物型4280引起。在明显增生开始之前，这种细菌会在降结肠产生紧密黏附并消除损伤。通过突变分析表明，弗氏柠檬酸杆菌生物型4280的染色体eae基因对于结肠定植是必需的。相反，去除了在弗氏柠檬酸杆菌生物型4280中鉴定出的一个65kb质粒的细菌，在结肠定植或诱导结肠增生方面并未减弱。
