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蒙古沙鼠(长爪沙鼠)白化病基因座上的第二个肢端黑素沉着等位基因。

A second acromelanistic allelomorph at the albino locus of the Mongolian gerbil (Meriones unguiculatus).

作者信息

Petrij F, van Veen K, Mettler M, Brückmann V

机构信息

Department of Clinical Genetics, Erasmus University, Rotterdam, The Netherlands.

出版信息

J Hered. 2001 Jan-Feb;92(1):74-8. doi: 10.1093/jhered/92.1.74.

Abstract

A new autosomal recessive coat color mutant in the Mongolian gerbil (Meriones unguiculatus) is described: chinchilla medium (symbol c(chm)). The mutant has typical acromelanistic features similar to those of several acromelanistic c locus mutants of other species of mammals. Previously a more severe form of acromelanism (c(h)c(h)) has been described in the Mongolian gerbil. The new allele shows to be allelic with this form. On a nonagouti background compound heterozygotes (aac(chm)c(h)) show an intermediate phenotype that is very similar to that of the Siamese mouse (Mus musculus) and rat (Rattus norvegicus). Homozygotes (aac(chm)c(chm)) display a very dark acromelanistic phenotype reminiscent of that of the sable rabbit (Oryctolagus cuniculus). The gray phenotype (gg) in the Mongolian gerbil resembles the albino locus phenotype chinchilla (c(ch)c(ch)) in mice. We show that the new mutant is not allelic with gray. Fertility and viability of the new mutant are within normal range.

摘要

本文描述了蒙古沙鼠(长爪沙鼠,Meriones unguiculatus)中一种新的常染色体隐性毛色突变体:中青紫蓝(符号为c(chm))。该突变体具有典型的肢端黑素减退特征,与其他哺乳动物物种的几种肢端黑素减退c位点突变体相似。此前,在蒙古沙鼠中已描述过一种更严重的肢端黑素减退形式(c(h)c(h))。新等位基因显示与这种形式是等位基因。在非刺鼠背景下,复合杂合子(aac(chm)c(h))表现出一种中间表型,与暹罗小鼠(小家鼠,Mus musculus)和大鼠(褐家鼠,Rattus norvegicus)的表型非常相似。纯合子(aac(chm)c(chm))表现出一种非常深的肢端黑素减退表型,让人联想到紫貂兔(穴兔,Oryctolagus cuniculus)的表型。蒙古沙鼠中的灰色表型(gg)类似于小鼠白化位点的青紫蓝表型(c(ch)c(ch))。我们表明,新突变体与灰色不是等位基因。新突变体的生育力和活力在正常范围内。

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