Tuominen T, Jämsä T, Oksanen J, Tuukkanen J, Gao T J, Lindholm T S, Jalovaara P
Department of Surgery, University of Oulu, Finland.
Ann Chir Gynaecol. 2001;90(1):32-6.
Hydroxyapatite (HA) has been considered as a carrier material for bone morphogenetic proteins (BMP). The aim of this study was to evaluate the capacity of a composite implant of HA and native bovine BMP to heal a 2 cm segmental defect in the canine ulna.
A composite HA+BMP implant was compared with plain HA implants and cortical autografts. The fixation was accomplished with an intramedullary Kirschner wire. The bone union was evaluated by X-rays taken at operation and after 3, 6, 9, 12, 16, 25, 35 weeks and by histology and mechanical torsion tests.
HA implants were not able to produce complete bone union even with BMP. There was some bridging between the implant and the bone in the defects treated with either plain HA or HA+BMP implant, the bridging being slightly more pronounced with HA+BMP. The autografts showed a significantly better capacity to heal the defect. The HA implant did not resorb markedly during the study. There was no significant difference in mechanical strength between the HA and HA+BMP groups.
HA was not an adequate bone substitute material in this study model, and BMP was not able to enhance sufficiently the poor capacity of HA to heal canine ulnar defects.
羟基磷灰石（HA）一直被视为骨形态发生蛋白（BMP）的载体材料。本研究的目的是评估HA与天然牛BMP的复合植入物修复犬尺骨2cm节段性缺损的能力。
将HA+BMP复合植入物与单纯HA植入物及皮质骨自体移植物进行比较。采用髓内克氏针进行固定。通过术中及术后3、6、9、12、16、25、35周拍摄的X线片、组织学检查及机械扭转试验评估骨愈合情况。
即使添加了BMP，HA植入物也无法实现完全骨愈合。在单纯HA或HA+BMP植入物治疗的缺损中，植入物与骨之间有一些桥接，HA+BMP组的桥接稍明显。自体移植物显示出明显更好的愈合缺损的能力。在研究过程中，HA植入物没有明显吸收。HA组和HA+BMP组之间的机械强度没有显著差异。
在本研究模型中，HA不是一种合适的骨替代材料，BMP也不能充分增强HA修复犬尺骨缺损的较差能力。
