接受环孢素治疗的母亲进行母乳喂养。
Breast-feeding by a cyclosporine-treated mother.
作者信息
Munoz-Flores-Thiagarajan K D, Easterling T, Davis C, Bond E F
机构信息
Department of Biobehavioral Nursing and Health Systems, School of Nursing, University of Washington, Box 357266, Seattle, WA 98195, USA.
出版信息
Obstet Gynecol. 2001 May;97(5 Pt 2):816-8.
BACKGROUND
Cyclosporine is known to be excreted in breast milk, but levels in infants are not known. Post-transplant breast-feeding has been contraindicated in mothers treated with calcineurin inhibitors such as cyclosporine.
CASE
A 35-year-old woman exclusively breast-fed her infant during the first 10.5 months of life while she was being treated with cyclosporine. Cyclosporine measurements in infant and maternal blood and breast milk revealed a mean breast milk/maternal blood level ratio of 84%, but undetectable levels in the infant. The infant grew and developed normally.
CONCLUSION
The infant of a cyclosporine-treated mother was breast-fed exclusively during the first 10.5 months of life and did not absorb a detectable amount of the drug. Fetal growth and development were normal.
背景
已知环孢素可经母乳排泄，但婴儿体内的水平尚不清楚。接受环孢素等钙调神经磷酸酶抑制剂治疗的母亲进行移植后母乳喂养一直被视为禁忌。
病例
一名35岁女性在接受环孢素治疗期间，在婴儿出生后的前10.5个月进行纯母乳喂养。对婴儿、母亲血液及母乳中环孢素的检测显示，母乳与母亲血液中药物水平的平均比值为84%，但婴儿体内未检测到药物。婴儿生长发育正常。
结论
接受环孢素治疗的母亲所生婴儿在出生后的前10.5个月进行纯母乳喂养，未吸收可检测到量的该药物。胎儿生长发育正常。
Zotero 插件