Suppr超能文献

环孢素(CsA)在免疫性皮肤病中的作用。

Role of Cyclosporine (CsA) in Immuno-dermatological Conditions.

作者信息

Rajagopalan Murlidhar, Saraswat Abir, Chandrashekar Byalakere Shivanna, Dhar Sandipan, Dogra Sunil, Tahiliani Sushil, Raj Praveen

机构信息

Department of Dermatology, Apollo Hospital, Chennai, Tamil Nadu, India.

Department of Dermatology, Indushree Skin Clinic, Lucknow, Uttar Pradesh, India.

出版信息

Indian Dermatol Online J. 2022 Sep 5;13(5):585-599. doi: 10.4103/idoj.idoj_189_22. eCollection 2022 Sep-Oct.

Abstract

Cyclosporine (CsA) is a calcineurin inhibitor that acts selectively on T cells. It has been used in dermatology since 1997 for its US Food and Drug Administration indication of psoriasis and off-label for various other inflammatory skin conditions, including atopic dermatitis, alopecia areata, urticaria, lichen planus and many others in pediatric, adults as well as in pregnant women. However, clinicians' preferences for management differ, which may have a bearing on the treatment selection. Hence, the purpose of this review is to outline the role of CsA in various skin conditions through consensus statement from six national experts in the field of dermatology.

摘要

环孢素(CsA)是一种选择性作用于T细胞的钙调神经磷酸酶抑制剂。自1997年以来,它已被用于皮肤科,因为美国食品药品监督管理局批准其用于治疗银屑病,也被用于治疗各种其他炎症性皮肤病,包括特应性皮炎、斑秃、荨麻疹、扁平苔藓等,适用于儿童、成人以及孕妇。然而,临床医生在治疗管理上的偏好有所不同,这可能会影响治疗选择。因此,本综述的目的是通过皮肤科领域六位国内专家的共识声明,概述环孢素在各种皮肤疾病中的作用。

相似文献

1
Role of Cyclosporine (CsA) in Immuno-dermatological Conditions.
Indian Dermatol Online J. 2022 Sep 5;13(5):585-599. doi: 10.4103/idoj.idoj_189_22. eCollection 2022 Sep-Oct.
2
Cyclosporin in dermatology: A practical compendium.
Dermatol Ther. 2020 Nov;33(6):e13934. doi: 10.1111/dth.13934. Epub 2020 Sep 6.
3
The use of cyclosporine in dermatology.
J Drugs Dermatol. 2012 Aug;11(8):979-87.
4
The use of cyclosporine in dermatology: part I.
J Am Acad Dermatol. 2010 Dec;63(6):925-46; quiz 947-8. doi: 10.1016/j.jaad.2010.02.063.
6
Dissecting susceptibility from exogenous triggers: the model of alopecia areata and associated inflammatory skin diseases.
J Eur Acad Dermatol Venereol. 2015 Dec;29(12):2429-35. doi: 10.1111/jdv.13325. Epub 2015 Sep 28.
7
JAK-inhibitors in dermatology: current evidence and future applications.
J Dermatolog Treat. 2019 Nov;30(7):648-658. doi: 10.1080/09546634.2018.1546043. Epub 2018 Dec 3.
8
THE NEURODERMATOSIS.
Med J Aust. 1965 Mar 20;1(12):419-21.
10
Cyclosporine in Dermatology.
Skinmed. 2016 Apr 1;14(2):105-9. eCollection 2016.

引用本文的文献

1
Concerns Regarding Use of High-Dose Cyclosporine in the Management of Refractory Chronic Spontaneous Urticaria.
Indian Dermatol Online J. 2025 Apr 15;16(4):693-694. doi: 10.4103/idoj.idoj_1274_24. eCollection 2025 Jul-Aug.
2
Balancing efficacy and hepatotoxicity: a comprehensive review of oral medications in psoriasis management.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Jun 25. doi: 10.1007/s00210-025-04334-1.
3
Understanding the Intricate Pathophysiology of Psoriasis and Related Skin Disorders.
Int J Mol Sci. 2025 Jan 17;26(2):749. doi: 10.3390/ijms26020749.
4
Anti-psoriatic characteristics of ROCEN (topical Arthrocen) in comparison with Cyclosporine A in a murine model.
BMC Complement Med Ther. 2024 Feb 24;24(1):100. doi: 10.1186/s12906-024-04405-5.
5
Intradermal Delivery of Naked mRNA Vaccines via Iontophoresis.
Pharmaceutics. 2023 Nov 26;15(12):2678. doi: 10.3390/pharmaceutics15122678.

本文引用的文献

1
Systematic Review and Recommendations to Combine Newer Therapies With Conventional Therapy in Psoriatic Disease.
Front Med (Lausanne). 2021 Aug 19;8:696597. doi: 10.3389/fmed.2021.696597. eCollection 2021.
2
Oral cyclosporine is effective in stabilizing active vitiligo: Results of a randomized controlled trial.
Dermatol Ther. 2021 Sep;34(5):e15033. doi: 10.1111/dth.15033. Epub 2021 Jun 23.
3
Vaccinations in Patients Receiving Systemic Drugs for Skin Disorders: What Can We Learn for SARS-Cov-2 Vaccination Strategies?
Drugs R D. 2021 Sep;21(3):341-350. doi: 10.1007/s40268-021-00349-0. Epub 2021 Jun 9.
4
Efficacy and predictive factors of cyclosporine A in alopecia areata: a systematic review with meta-analysis.
J Dermatolog Treat. 2022 May;33(3):1643-1651. doi: 10.1080/09546634.2021.1886230. Epub 2021 Jul 26.
6
7
Immune Response to Vaccination in Patients with Psoriasis Treated with Systemic Therapies.
Vaccines (Basel). 2020 Dec 16;8(4):769. doi: 10.3390/vaccines8040769.
8
Systemic therapies for Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: a SCORTEN-based systematic review and meta-analysis.
J Eur Acad Dermatol Venereol. 2021 Jan;35(1):159-171. doi: 10.1111/jdv.16685. Epub 2020 Jul 23.
10
Covid-19 infection in psoriasis patients treated with cyclosporin.
Dermatol Ther. 2020 Jul;33(4):e13739. doi: 10.1111/dth.13739. Epub 2020 Jun 24.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验