Rajagopalan Murlidhar, Saraswat Abir, Chandrashekar Byalakere Shivanna, Dhar Sandipan, Dogra Sunil, Tahiliani Sushil, Raj Praveen
Department of Dermatology, Apollo Hospital, Chennai, Tamil Nadu, India.
Department of Dermatology, Indushree Skin Clinic, Lucknow, Uttar Pradesh, India.
Indian Dermatol Online J. 2022 Sep 5;13(5):585-599. doi: 10.4103/idoj.idoj_189_22. eCollection 2022 Sep-Oct.
Cyclosporine (CsA) is a calcineurin inhibitor that acts selectively on T cells. It has been used in dermatology since 1997 for its US Food and Drug Administration indication of psoriasis and off-label for various other inflammatory skin conditions, including atopic dermatitis, alopecia areata, urticaria, lichen planus and many others in pediatric, adults as well as in pregnant women. However, clinicians' preferences for management differ, which may have a bearing on the treatment selection. Hence, the purpose of this review is to outline the role of CsA in various skin conditions through consensus statement from six national experts in the field of dermatology.
环孢素(CsA)是一种选择性作用于T细胞的钙调神经磷酸酶抑制剂。自1997年以来,它已被用于皮肤科,因为美国食品药品监督管理局批准其用于治疗银屑病,也被用于治疗各种其他炎症性皮肤病,包括特应性皮炎、斑秃、荨麻疹、扁平苔藓等,适用于儿童、成人以及孕妇。然而,临床医生在治疗管理上的偏好有所不同,这可能会影响治疗选择。因此,本综述的目的是通过皮肤科领域六位国内专家的共识声明,概述环孢素在各种皮肤疾病中的作用。