Bhutani B R, Bhatia V N
J Pharm Sci. 1975 Jan;64(1):135-9. doi: 10.1002/jps.2600640132.
The design and construction of a laboratory size dryer and other accessories suitable for investigating the drying rate kinetics of granules under controlled external conditions are described. Granulations of lactose and sulfathiazole, representing water-soluble and insoluble materials, were prepared using various commonly used binders, and their drying rates were determined. The binders and diluents affected the drying rate curves for these granulations both qualitatively and quantitatively. Granules made with starch paste and gelatin solution required maximum time and energy for drying and those made with simply syrup USP required the least among the binders studied. Generally, three linear slopes were observed when the drying rate was plotted against the moisture remaining, indicating that granulation drying may be considered as occurring through three distinct phases.
描述了一种实验室规模干燥机及其他配件的设计与构造，这些配件适用于在可控外部条件下研究颗粒的干燥速率动力学。使用各种常用粘合剂制备了代表水溶性和不溶性材料的乳糖和磺胺噻唑颗粒，并测定了它们的干燥速率。粘合剂和稀释剂在定性和定量方面都影响了这些颗粒的干燥速率曲线。在研究的粘合剂中，用淀粉糊和明胶溶液制成的颗粒干燥所需时间和能量最多，而用美国药典简单糖浆制成的颗粒所需时间和能量最少。一般来说，当将干燥速率与剩余水分作图时，会观察到三个线性斜率，这表明颗粒干燥可被视为通过三个不同阶段进行。
