Opankunle W O, Bhutani B R, Bhatia V N
J Pharm Sci. 1975 Jun;64(6):1023-6. doi: 10.1002/jps.2600640631.
The effects of the granule size and density on the drying rate kinetics of tablet granulations were studied using lactose and sulfathiazole granules prepared with acacia mucilage and providone solution. The drying rate kinetics consisted of three distinct phases of drying when the drying rate was platted against remaining moisture content: constant rate, first falling rate, and second falling rate periods. The effect of various statistical diameters and granular density on the drying rate during the first falling rate period was analyzed, and the mechanism of moisture migration during this phase of drying was identified.
使用阿拉伯胶黏液和聚维酮溶液制备的乳糖和磺胺噻唑颗粒，研究了颗粒大小和密度对片剂颗粒干燥速率动力学的影响。当将干燥速率与剩余水分含量绘制成图时，干燥速率动力学包括三个不同的干燥阶段：恒速期、第一降速期和第二降速期。分析了各种统计直径和颗粒密度对第一降速期干燥速率的影响，并确定了该干燥阶段水分迁移的机制。
