Bettencourt A, Calado A, Amaral J, Vale F M, Rico J M, Monteiro J, Castro M
Faculdade de Farmácia, Universidade de Lisboa, Av. das Forcas Armadas, 1600-083, Lisbon, Portugal.
Int J Pharm. 2001 May 21;219(1-2):89-93. doi: 10.1016/s0378-5173(01)00630-5.
Polymethylmethacrylate (PMMA) bone cement is a biomaterial used to anchor prostheses during joint replacement surgery. Residual methylmethacrylate monomer (MMA) may be related with the cytotoxic effect of PMMA. The aim of the present paper was to investigate the effect of two different cement mixing methods: hand stirring at atmospheric pressure and under partial vacuum (0.330 and 0.154 bar) on residual monomer liberation in phosphate buffer saline solution from acrylic cement powder. Residual MMA content was determined by high-performance liquid chromatography. Mathematical models were applied to experimental dissolution data revealing that monomer release was significantly reduced in bone cement powder obtained at 0.154 bar vacuum pressure compared to the other mixing conditions. The kinetic models applied are consistent with a simple diffusion mechanism of the monomer from the polymer matrix.
聚甲基丙烯酸甲酯（PMMA）骨水泥是一种在关节置换手术中用于固定假体的生物材料。残留的甲基丙烯酸甲酯单体（MMA）可能与PMMA的细胞毒性作用有关。本文的目的是研究两种不同的骨水泥混合方法：在大气压下手工搅拌以及在部分真空（0.330和0.154巴）下搅拌对丙烯酸骨水泥粉末在磷酸盐缓冲盐溶液中残留单体释放的影响。通过高效液相色谱法测定残留MMA含量。将数学模型应用于实验溶解数据，结果表明，与其他混合条件相比，在0.154巴真空压力下获得的骨水泥粉末中单体释放显著减少。所应用的动力学模型与单体从聚合物基质中的简单扩散机制一致。
