Rini Josephine N, Núñez Rodolfo, Nichols Kenneth, Tronco Gene G, Tomas Maria Bernadette, Hart Diane, Karayalcin Gungor, Leonidas John C, Palestro Christopher J
Division of Nuclear Medicine, Long Island Jewish Medical Center, 270-05 76th Avenue, New Hyde Park, NY 11040, USA
Pediatr Radiol. 2005 Feb;35(2):169-78. doi: 10.1007/s00247-004-1325-2. Epub 2004 Nov 12.
Coincidence-detection 18F-FDG-PET (PET) and 67Ga whole-body and SPECT (Ga) were compared in children and young adults with newly diagnosed Hodgkin's disease (HD).
Thirty patients with histologically confirmed HD underwent PET with attenuation correction 1 h after injection of 150-220 MBq 18F-FDG and whole-body and SPECT imaging 72 h after injection of 250-370 MBq 67Ga citrate. Two experienced readers retrospectively reviewed PET and Ga scans, grading 13 anatomic regions from one (normal) to five (abnormal). Numerical stages were assigned based on Ann Arbor classification. Comparison was made with disease sites (established by biopsy or two or more of the following: physical examination, conventional imaging studies, radionuclide studies, and follow-up studies) and clinical stages. Sensitivity, specificity, and accuracy were calculated and significance of differences determined using McNemar's test.
PET detected 120/138 (87%) disease sites and Ga 109/138 (79%). PET and Ga were concordant for 103/138 (75%) sites. Accuracies were not significantly different for supradiaphragmatic disease. PET was more accurate than Ga for detecting splenic (0.91 vs 0.61, P = 0.012), infradiaphragmatic (0.89 vs 0.75, P = 0.042), and all disease sites combined (0.95 vs 0.91, P = 0.039). PET stage agreed with clinical stage in 79% of patients and Ga in 71%.
PET was superior to Ga for evaluating children and young adults with newly diagnosed HD.
对新诊断的霍奇金淋巴瘤（HD）儿童和年轻成人进行了符合探测18F-FDG-PET（PET）与67Ga全身显像及SPECT（Ga）的比较。
30例经组织学确诊的HD患者，在注射150 - 220 MBq 18F-FDG后1小时进行有衰减校正的PET检查，并在注射250 - 370 MBq 67Ga柠檬酸盐后72小时进行全身及SPECT显像。两名经验丰富的阅片者对PET和Ga扫描进行回顾性分析，对13个解剖区域从1级（正常）到5级（异常）进行分级。根据Ann Arbor分类法确定数字分期。将其与疾病部位（通过活检或以下两项或更多项确定：体格检查、传统影像学检查、放射性核素检查和随访研究）及临床分期进行比较。计算敏感性、特异性和准确性，并使用McNemar检验确定差异的显著性。
PET检测到120/138（87%）个疾病部位，Ga检测到109/138（79%）个。PET和Ga在103/138（75%）个部位结果一致。对于膈上疾病，两者的准确性无显著差异。PET在检测脾脏（0.91对0.61，P = 0.012）、膈下（0.89对0.75，P = 0.042）以及所有合并的疾病部位（0.95对0.91，P = 0.039）方面比Ga更准确。PET分期与79%的患者临床分期一致，Ga与71%的患者临床分期一致。
在评估新诊断的HD儿童和年轻成人方面，PET优于Ga。
