Kastanioudakis I, Ziavra N, Politi E N, Exarchakos G, Drosos A A, Skevas A
Department of Otolaryngology, Medical School, University of Ioannina, Greece.
Otolaryngol Head Neck Surg. 2001 May;124(5):522-5. doi: 10.1067/mhn.2001.115092.
To investigate the middle and inner ear involvement in patients with progressive systemic sclerosis (PSS).
We prospectively evaluated 34 PSS patients. All patients underwent a complete ear-nose-throat physical examination and audiological evaluation with pure tone, impedance, and speech audiometry. In addition, systemic manifestations of the disease and drug therapy were recorded. Finally, all patients were tested for the presence of autoantibodies. The results were compared with those of 45 age-matched healthy subjects.
We found a sensorineural hearing loss in 20% and mixed type hearing loss in 3.3% of the patients. There was no correlation of hearing loss with age, systemic manifestations of the disease, presence of autoantibodies, and drug therapy. Ten percent of the patients had patulous eustachian tubes.
One fourth of PSS patients had a hearing loss affecting the middle and mainly the high frequencies. This is a lower percentage than that reported by other investigators. A significant prevalence of bilateral patulous eustachian tubes was noticed as well. Further investigation is needed for a better understanding of the mechanism of ear damage in PSS patients.
研究进行性系统性硬化症（PSS）患者的中耳和内耳受累情况。
我们对34例PSS患者进行了前瞻性评估。所有患者均接受了全面的耳鼻喉体格检查以及纯音、声阻抗和言语测听的听力学评估。此外，记录了疾病的全身表现和药物治疗情况。最后，对所有患者进行了自身抗体检测。将结果与45名年龄匹配的健康受试者的结果进行比较。
我们发现20%的患者存在感音神经性听力损失，3.3%的患者存在混合性听力损失。听力损失与年龄、疾病的全身表现、自身抗体的存在以及药物治疗均无相关性。10%的患者咽鼓管异常开放。
四分之一的PSS患者存在听力损失，主要影响中耳且以高频为主。这一比例低于其他研究者报告的比例。还发现双侧咽鼓管异常开放的发生率较高。需要进一步研究以更好地了解PSS患者耳部损伤的机制。
